# 纤维性骨病变（Fibro osseous Lesion）

- 器官 / 系统：骨 / 骨骼肌肉系统（bone / musculoskeletal-system）
- NTP 数据编号：ntp-0576
- 规范 URL：https://www.labsmart.cn/ntp/bone-fibro-osseous-lesion.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#bone-fibro-osseous-lesion
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/musculoskeletal-system/bone/Fibro-osseousLesion
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
纤维骨性病变（fibro-osseous lesions，FOLs）常见于多种小鼠品系的胸骨节、椎骨、胫骨、股骨及其他骨骼。

## 病变描述（中文）
纤维骨性病变（fibro-osseous lesions，FOLs）常见于多种小鼠品系的胸骨节、椎骨、胫骨、股骨及其他骨骼。FOL 在 B6C3F1 小鼠中的发生率高于其他品系，并且是 B6C3F1 小鼠中最常见的原发性骨病变。该病变尚未在大鼠中报道。这些病变的特征是骨小梁和骨髓腔被纤维血管性间质部分或完全取代，该间质含有嵌入嗜酸性基质中的成纤维细胞、破骨细胞和成骨细胞（Figure 1、Figure 2）。其组织病理学特征与纤维性骨营养不良相似；然而，FOL 发生于无甲状旁腺或肾脏改变的情况下，通常以 局灶性（focal） 病变形式出现在干骺端或骨内膜区域（Figure 3），并可能进展累及更大范围的骨组织（Figure 4）。FOL 的发生率随年龄增长而增加，且最常发生于雌性小鼠（B6C3F1 雌性中发生率为 40–100%，雄性中 <1%），提示雌激素参与其中。这些病变常伴有与雌激素过多症相符的子宫或卵巢改变（子宫内膜囊性增生、阴道上皮细胞增生及角化过度、卵泡发育/闭锁及囊肿）。然而，这些病变也发生于卵巢切除的雌性小鼠和去势的雄性小鼠中。历史上，FOL 曾被冠以多种名称，包括纤维骨性发育不良、纤维性发育不良、局灶性 骨营养不良、骨发育不良、骨纤维化及骨营养不良，但这些病变的首选术语是“纤维骨性病变（fibro-osseous lesion）”。

## 诊断与分级建议（NTP 共识，中文）
尽管这是 B6C3F1 小鼠中相当常见的年龄相关背景病变，但 FOL 的发生率和严重程度可能受到具有雌激素效应的化合物处理的影响。因此，只要存在该病变，就应当作出诊断、给出严重程度分级，并在叙述中予以描述。小鼠中晚期 FOL 在组织学上与纤维性骨营养不良无法区分。因此，当在小鼠中观察到该病变处于晚期状态且无甲状旁腺或肾脏病变时，应当作出 FOL 的诊断。如果该病变与慢性肾脏疾病或增生性甲状旁腺病变同时发生，则应当作出纤维性骨营养不良的诊断（见 Bone - Fibrous Osteodystrophy）。相关链接：Bone - Fibrous Osteodystrophy

## 英文原文 · Comment
Fibro-osseous lesions (FOLs) arise commonly within the sternebrae, vertebrae, tibias, femurs, and other bones in a variety of mouse strains. The incidence of FOL is higher in B6C3F1 mice than in other strains, and it is the most common primary bone lesion in B6C3F1 mice. This lesion has not been reported in the rat. These lesions are characterized by partial or complete replacement of bony trabeculae and marrow cavity by fibrovascular stroma containing fibroblasts, osteoclasts, and osteoblasts embedded in eosinophilic matrix ( Figure 1 and Figure 2 ). The histopathologic features are similar to fibrous osteodystrophy; however, FOLs occur in the absence of parathyroid or renal alterations, typically arise as focal lesions within the metaphyseal or endocortical regions ( Figure 3 ), and may progress to involve larger areas of the bone ( Figure 4 ). FOL increases in incidence with age and arises most often in female mice (40–100% incidence in B6C3F1 females, <1% in males), suggesting involvement of estrogens. These lesions are often accompanied by alterations in the uterus or ovary consistent with hyperestrogenism (endometrial cystic hyperplasia, vaginal epithelial cell hyperplasia and hyperkeratosis, ovarian follicular development/atresia and cysts). However, these lesions also arise in ovariectomized female mice and castrated males. Historically, FOL has been referred to by a variety of names, including fibro-osseous dysplasia, fibrous dysplasia, focal osteodystrophy, osteodysplasia, osteofibrosis, and osteodystrophy, but the preferred term for these lesions is "fibro-osseous lesion."

## 英文原文 · Recommendation
Although this is a fairly common age-related background lesion in the B6C3F1 mouse, the incidence and severity of FOL may be influenced by treatment with compounds that possess estrogenic effects. Therefore, this lesion should be diagnosed, given a severity grade, and described in the narrative whenever present. Advanced FOL in mice is indistinguishable histologically from fibrous osteodystrophy. Therefore, when this lesion is observed in mice in an advanced state and in the absence of parathyroid or renal lesions, the diagnosis of FOL should be made. If the lesion occurs concurrently with chronic renal disease or proliferative parathyroid lesions, the diagnosis of fibrous osteodystrophy should be made (see Bone - Fibrous Osteodystrophy ). Related Links: Bone - Fibrous Osteodystrophy

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0506.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0510.jpg

整理：北京天融慧通科技有限责任公司（LabSmart）｜ https://www.labsmart.cn