# 萎缩（Atrophy）

- 器官 / 系统：阴蒂腺 / 雌性生殖系统（clitoral-gland / reproductive-system-female）
- NTP 数据编号：ntp-0556
- 规范 URL：https://www.labsmart.cn/ntp/clitoral-gland-atrophy.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#clitoral-gland-atrophy
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/clitoral-gland/Atrophy
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
阴蒂腺（clitoral gland）实质萎缩是小鼠和大鼠中一种自发性的衰老性改变。

## 病变描述（中文）
阴蒂腺（clitoral gland）实质萎缩是小鼠和大鼠中一种自发性的衰老性改变。萎缩常伴随导管扩张（Figure 1）。轻度炎症细胞浸润也可能与腺体组织减少有关。萎缩的标志性特征是阴蒂腺腺泡组织数量减少；单个腺泡由少量皮脂腺细胞构成，这些细胞含有数量不等的深嗜酸性分泌颗粒。常见侧导管因分泌物蓄积而扩张、显著（Figure 2、Figure 3）。间质纤维组织常增多（Figure 2、Figure 3、Figure 4、Figure 5）。

## 诊断与分级建议（NTP 共识，中文）
阴蒂腺萎缩一旦出现即应作出诊断并给出严重程度分级。伴随阴蒂腺萎缩的炎症不应单独诊断，除非其严重程度足以支持单独诊断。若萎缩继发于导管扩张，则萎缩无需单独诊断，但若与受试物相关，则应在叙述中予以描述。

## 英文原文 · Comment
Atrophy of clitoral gland parenchyma is a spontaneous aging change in mice and rats. Atrophy also accompanies duct dilatation ( Figure 1 ). Mild inflammatory cell infiltrate may also be associated with the reduction in glandular tissue. The hallmark of atrophy is a reduction in the amount of acinar tissue of the clitoral gland; individual acini are composed of small numbers of sebaceous cells containing variable amounts of dark eosinophilic secretory granules. Frequently the lateral ducts, distended by accumulated secretion, are prominent ( Figure 2 and Figure 3 ). There is often an increase in the interstitial fibrous tissue ( Figure 2 , Figure 3 , Figure 4 , and Figure 5 ).

## 英文原文 · Recommendation
Clitoral gland atrophy should be diagnosed and given a severity grade whenever it is present. Inflammation accompanying clitoral gland atrophy should not be diagnosed separately unless warranted by severity. If atrophy is secondary to duct dilation, then atrophy does not need to be diagnosed separately but should be described in the narrative if treatment related.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0593.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0599.jpg

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