色素Pigment · 阴蒂腺 · 雌性生殖系统 · NTP ntp-0555

Comment：
Clitoral gland pigmentation ( Figure 1 and Figure 2 ) may be an age-associated degenerative change but may also be seen as a sequela of cell damage (ceroid or lipofuscin) or hemorrhage (hemosiderin). It often accompanies clitoral gland atrophy. Lipofuscin has been reported in the cytoplasm of individual acinar cells.

Recommendation：
Pigment should be diagnosed when it is considered to be relevant to the study (or if it is unclear whether it is relevant to the study) or if it is unusually prominent. Not all pigments have to be diagnosed, as some are ubiquitous in aging animals or are secondary to another disease process (e.g., hemorrhage) and not toxicologically meaningful. The pathologist should use his or her judgment in deciding whether or not the pigment should be diagnosed. When pigment is seen concurrently with atrophy, the pigment should not be diagnosed separately but may be described in the pathology narrative. Definitive pigment identification is often difficult in histologic sections, even with a battery of special stains. Therefore, a diagnosis of “pigment” (as opposed to diagnosing the type of pigment, e.g., hemosiderin or lipofuscin) is most appropriate. The pathology narrative should describe the morphologic features of the pigmentation. When pigment is diagnosed, it should be given a severity grade.