# 淀粉样物质（Amyloid）

- 器官 / 系统：附睾 / 雄性生殖系统（epididymis / reproductive-system-male）
- NTP 数据编号：ntp-0499
- 规范 URL：https://www.labsmart.cn/ntp/epididymis-amyloid.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#epididymis-amyloid
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/epididymis/Amyloid
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
淀粉样变性（amyloidosis）是一种与年龄相关的偶然性背景病变，最常见于小鼠。

## 病变描述（中文）
淀粉样变性（amyloidosis）是一种与年龄相关的偶然性背景病变，最常见于小鼠。它通常是一种全身性病变，但附睾是常见的沉积部位。其表现为淡染、嗜酸性细胞外物质，刚果红（Congo red）染色后在偏振光下呈绿色双折射。

## 诊断与分级建议（NTP 共识，中文）
淀粉样物质应记录并分级，如果其发生率和/或严重程度似乎与化学物给药相关，则应在病理学叙述中讨论。相关或继发性病变除非其严重程度足以需要诊断，否则不必诊断。

## 英文原文 · Comment
Amyloidosis is an age-related, incidental background finding most commonly seen in mice. It is generally a systemic condition, but the epididymis is a common site for deposition. It appears as pale, eosinophilic extracellular material that has a green birefringence under polarized light when stained with Congo red.

## 英文原文 · Recommendation
Amyloid should be recorded and graded and should be discussed in the pathology narrative if the incidence and/or severity appear to be related to chemical administration. Associated or secondary lesions need not be diagnosed unless warranted by their severity.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0730.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0727.jpg

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