# 精子停滞（Sperm Stasis）

- 器官 / 系统：附睾 / 雄性生殖系统（epididymis / reproductive-system-male）
- NTP 数据编号：ntp-0501
- 规范 URL：https://www.labsmart.cn/ntp/epididymis-sperm-stasis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#epididymis-sperm-stasis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/epididymis/SpermStasis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
精子停滞（sperm stasis）最常见于睾丸停止产生精子后，发生于附睾尾。精子被隔离在尾部管道内，呈强嗜酸性（Figure 1、Figure 2、Figure 3）。

## 病变描述（中文）
精子停滞（sperm stasis）最常见于睾丸停止产生精子后，发生于附睾尾。精子被隔离在尾部管道内，呈强嗜酸性（Figure 1、Figure 2、Figure 3）。较近端的管道通常无精子。由阻塞性病变引起的精子停滞也可发生于附睾头和输出管。在 Figure 4 中，被隔离的精子呈嗜碱性。如果上皮衬里破损，精子进入间质，精子停滞可进展为精子肉芽肿（sperm granuloma）。

## 诊断与分级建议（NTP 共识，中文）
精子停滞应记录并分级，如果其发生率和/或严重程度似乎与化学物给药相关，应在病理学叙述中讨论。当双侧附睾均受累时，应注明双侧，严重程度分级基于受累更严重的附睾。应在病理学叙述中注明与任何生精障碍的相关性，以助于解释。

## 英文原文 · Comment
Sperm stasis is most commonly seen in the cauda epididymis following cessation of sperm production by the testis. Sperm become sequestered in the caudal ducts and are intensely eosinophilic ( Figure 1 , Figure 2 , and Figure 3 ). The more proximal ducts are generally empty of sperm. Sperm stasis also occurs in the caput and efferent ducts as a result of obstructive lesions. In Figure 4 , the sequestered sperm are basophilic. Sperm stasis may progress to sperm granuloma if the epithelial lining is breached and sperm gain access to the interstitium.

## 英文原文 · Recommendation
Sperm stasis should be recorded and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. Bilateral should be indicated when both epididymides are involved, with severity grade based on the more severely affected epididymis. Correlation with any spermatogenic disturbances should be noted in the pathology narrative to aid interpretation. Pagination Figure 1 of 4 Next page › Epididymis - Sperm Stasis. Ducts filled with sperm in a male B6C3F1 mouse from a chronic study. Enlarge Image All Images Enlarge All Images Epididymis - Sperm Stasis. Ducts filled with sperm in a male B6C3F1 mouse from a chronic study. "> Epididymis - Sperm Stasis. Ducts filled with sperm in a male B6C3F1 mouse from a chronic study. " /> Epididymis - Sperm Stasis. Ducts filled with sperm in a male B6C3F1 mouse from a chronic study. Epididymis - Sperm Stasis. Higher magnification of Figure 1 showing ducts filled with sperm in a male B6C3F1 mouse from a chronic study. "> Epididymis - Sperm Stasis. Higher magnification of Figure 1 showing ducts filled with sperm in a male B6C3F1 mouse from a chronic study. " /> Epididymis - Sperm Stasis. Higher magnification of Figure 1 showing ducts filled with sperm in a male B6C3F1 mouse from a chronic study. Epididymis - Sperm Stasis. Sperm stasis is present on the left and ducts without sperm on the right in a male B6C3F1 mouse from a subchronic study. "> Epididymis - Sperm Stasis. Sperm stasis is present on the left and ducts without sperm on the right in a male B6C3F1 mouse from a subchronic study. " /> Epididymis - Sperm Stasis. Sperm stasis is present on the left and ducts without sperm on the right in a male B6C3F1 mouse from a subchronic study. Epididymis - Sperm Stasis. Sperm stasis is present on the left and atrophic epididymal ducts on the right in a male F344/N rat from a chronic study. "> Epididymis - Sperm Stasis. Sperm stasis is present on the left and atrophic epididymal ducts on the right in a male F344/N rat from a chronic study. " /> Epididymis - Sperm Stasis. Sperm stasis is present on the left and atrophic epididymal ducts on the right in a male F344/N rat from a chronic study.

## 配图
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- https://www.labsmart.cn/ntp-atlas-images/ntp_0753.jpg

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