# 肌层变性(Muscularis Degeneration) - 器官 / 系统:食管 / 消化系统(esophagus / alimentary-system) - NTP 数据编号:ntp-0309 - 规范 URL:https://www.labsmart.cn/ntp/esophagus-muscularis-degeneration.html - 中文图谱总页锚点:https://www.labsmart.cn/ntp-atlas.html#esophagus-muscularis-degeneration - 原始出处:https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/esophagus/Muscularis-Degeneration - 授权:美国联邦政府作品,公有领域;引用请标注 NTP Nonneoplastic Lesion Atlas - 适用说明:仅供科研使用,不用于临床诊断 ## 一句话结论 变性(degeneration)的特征是纤维体积减小(Figure 1、Figure 2)、过度收缩、“纤维扭曲卷曲”、细胞质呈均质嗜酸性至颗粒状或絮状、横纹消失以及矿化。 ## 病变描述(中文) 变性(degeneration)的特征是纤维体积减小(Figure 1、Figure 2)、过度收缩、“纤维扭曲卷曲”、细胞质呈均质嗜酸性至颗粒状或絮状、横纹消失以及矿化。巨噬细胞(macrophage)(Figure 3、Figure 4)常见于肌肉变性和坏死区域。灌胃创伤可导致食管肌壁损伤,引起肌肉变性和坏死或穿孔。 ## 诊断与分级建议(NTP 共识,中文) 只要存在,肌层(tunica muscularis)的变性即应诊断为“食管,肌层 - 变性”,并根据病变范围进行分级。病理学家认为该病变系化学暴露所致还是灌胃操作失误所致,应在文字描述中注明。 ## 英文原文 · Comment Degeneration is characterized by decreased fiber size ( Figure 1 and Figure 2 ), hypercontraction, "twisting and curling of fibers," homogeneous eosinophilic to granular or floccular cytoplasm, loss of striations, and mineralization. Macrophages ( Figure 3 and Figure 4 ) are frequently found in areas of muscle degeneration and necrosis. Gavage trauma can result in damage to the muscular wall of the esophagus, resulting in muscle degeneration and necrosis or perforation. ## 英文原文 · Recommendation Whenever present, degeneration of the tunica muscularis should be diagnosed as "esophagus, muscularis - degeneration" and graded based upon the extent of the lesion. It should be noted in the narrative whether the pathologist considers this lesion to be due to chemical exposure or a gavage error. ## 配图 - https://www.labsmart.cn/ntp-atlas-images/ntp_0016.jpg - https://www.labsmart.cn/ntp-atlas-images/ntp_0018.jpg 整理:北京天融慧通科技有限责任公司(LabSmart)| https://www.labsmart.cn