# 角膜坏死（Cornea Necrosis）

- 器官 / 系统：眼 / 特殊感觉系统（eye / special-senses-system）
- NTP 数据编号：ntp-0346
- 规范 URL：https://www.labsmart.cn/ntp/eye-cornea-necrosis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#eye-cornea-necrosis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Cornea-Necrosis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
角膜上皮细胞坏死（necrosis of corneal epithelial cells）的特征是皱缩、嗜酸性增多的坏死细胞（提示为单细胞坏死）散布于上皮层中（Figure 1、Figure 2）。

## 病变描述（中文）
角膜上皮细胞坏死（necrosis of corneal epithelial cells）的特征是皱缩、嗜酸性增多的坏死细胞（提示为单细胞坏死）散布于上皮层中（Figure 1、Figure 2）。这些细胞还可能表现为与相邻细胞失去附着。上皮坏死可进展为糜烂和溃疡。其他角膜细胞类型（例如角膜内皮细胞和基质角膜细胞）也可发生坏死。角膜上皮坏死可能伴有上皮增生或炎症。

## 诊断与分级建议（NTP 共识，中文）
角膜坏死一经出现即应诊断，并赋予严重程度分级。角膜坏死的亚部位（上皮、内皮、基质）可在病理学描述中说明。相关病变（例如炎症）应单独诊断。

## 英文原文 · Comment
Necrosis of corneal epithelial cells is characterized by shrunken, hypereosinophilic necrotic cells (suggestive of single-cell necrosis) are scattered through the epithelium ( Figure 1 and Figure 2 ). The cells may also appear to have lost their attachments to adjacent cells. Epithelial necrosis can progress to erosion and ulceration. Other corneal cell types (e.g., corneal endothelial cells and stromal keratocytes) can also undergo necrosis. Corneal epithelial necrosis may be accompanied by epithelial hyperplasia or inflammation.

## 英文原文 · Recommendation
Corneal necrosis should be diagnosed whenever present and assigned a severity grade. The subtopography of corneal necrosis (epithelium, endothelium, stroma) can be described in the pathology narrative. Associated lesions (e.g., inflammation) should be diagnosed separately.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0978.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0977.jpg

整理：北京天融慧通科技有限责任公司（LabSmart）｜ https://www.labsmart.cn