# 巩膜骨性化生(Sclera Metaplasia Osseous) - 器官 / 系统:眼 / 特殊感觉系统(eye / special-senses-system) - NTP 数据编号:ntp-0328 - 规范 URL:https://www.labsmart.cn/ntp/eye-sclera-metaplasia-osseous.html - 中文图谱总页锚点:https://www.labsmart.cn/ntp-atlas.html#eye-sclera-metaplasia-osseous - 原始出处:https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Sclera-MetaplasiaOsseous - 授权:美国联邦政府作品,公有领域;引用请标注 NTP Nonneoplastic Lesion Atlas - 适用说明:仅供科研使用,不用于临床诊断 ## 一句话结论 巩膜骨性化生(osseous metaplasia)是一种随年龄增长而发生的偶然性改变,在Fischer 344/N大鼠中频繁发生,在其他常见大鼠品系中较少发生,而在小鼠中即使有也极为罕见。 ## 病变描述(中文) 巩膜骨性化生(osseous metaplasia)是一种随年龄增长而发生的偶然性改变,在Fischer 344/N大鼠中频繁发生,在其他常见大鼠品系中较少发生,而在小鼠中即使有也极为罕见。其表现为单个至多个、离散的、分化良好的矿化骨灶。偶尔可观察到类似的巩膜软骨灶(软骨性化生,cartilaginous metaplasia)。这些无害的结构不会引起巩膜或邻近组织的病理学改变。 ## 诊断与分级建议(NTP 共识,中文) 巩膜骨性化生只有在与处理相关时才应诊断,但不需要严重程度分级(即应记录为“存在”)。 ## 英文原文 · Comment Osseous metaplasia of the sclera is an incidental aging change that occurs frequently in Fischer 344/N rats, less often in other common rat strains, and seldom if ever in mice. It consists of single to multiple, discrete foci of well-differentiated, mineralized bone. Occasionally, similar scleral foci of cartilage are observed (cartilaginous metaplasia). These innocuous structures do not incite pathologic changes in the sclera or adjacent tissues. ## 英文原文 · Recommendation Scleral osseous metaplasia should be diagnosed only if treatment related, but it does not need a severity grade (i.e., it should be recorded as "present"). ## 配图 - https://www.labsmart.cn/ntp-atlas-images/ntp_1013.jpg - https://www.labsmart.cn/ntp-atlas-images/ntp_1012.jpg 整理:北京天融慧通科技有限责任公司(LabSmart)| https://www.labsmart.cn