# 透明滴蓄积（Hyaline Droplet Accumulation）

- 器官 / 系统：胆囊 / 肝胆系统（gallbladder / hepatobiliary-system）
- NTP 数据编号：ntp-0427
- 规范 URL：https://www.labsmart.cn/ntp/gallbladder-hyaline-droplet-accumulation.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#gallbladder-hyaline-droplet-accumulation
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/gallbladder/HyalineDropletAccumulation
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
在年龄较大的小鼠中，肝内胆管上皮细胞以及胆囊上皮细胞中可见由均质嗜酸性透明样物质构成的胞质内包涵体（Figure 1、Figure 2、Figure 3）。

## 病变描述（中文）
在年龄较大的小鼠中，肝内胆管上皮细胞以及胆囊上皮细胞中可见由均质嗜酸性透明样物质构成的胞质内包涵体（Figure 1、Figure 2、Figure 3）。在显著（marked）的病例中，可见腺上皮增生，且嗜酸性包涵体物质的结晶形态可能同时存在于细胞内和细胞外。该透明样物质已被鉴定为一种功能未知的几丁质酶样蛋白。

## 诊断与分级建议（NTP 共识，中文）
透明滴积聚应当被诊断并给出严重程度分级，且应在病理学叙述中描述其显著特征。相关病变，如炎症或上皮细胞变性、坏死或增生，若足够显著，应当单独诊断。

## 英文原文 · Comment
Cytoplasmic inclusions of homogeneous eosinophilic hyaline-like material may be seen in older mice in intrahepatic biliary epithelial cells, as well as epithelial cells in the gallbladder ( Figure 1 , Figure 2 , and Figure 3 ). In marked cases, there is hyperplasia of the glandular epithelium, and crystalline forms of the eosinophilic inclusion material may be present both intracellularly and extracellularly. The hyaline material has been identified as a chitinase-like protein of unknown function.

## 英文原文 · Recommendation
Hyaline droplet accumulation should be diagnosed and given a severity grade, and salient features should be described in the pathology narrative. Associated lesions, such as inflammation or epithelial cell degeneration, necrosis, or hyperplasia, should be diagnosed separately if sufficiently prominent.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0333.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0328.jpg

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