# 透明性肾小球病（Hyaline Glomerulopathy）

- 器官 / 系统：肾脏 / 泌尿系统（kidney / urinary-system）
- NTP 数据编号：ntp-0182
- 规范 URL：https://www.labsmart.cn/ntp/kidney-hyaline-glomerulopathy.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#kidney-hyaline-glomerulopathy
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/kidney/HyalineGlomerulopathy
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
透明样肾小球病（hyaline glomerulopathy）在B6C3F1小鼠中可作为自发性及/或治疗相关性疾病发生，在F344/N大鼠中则为治疗相关性疾病。

## 病变描述（中文）
透明样肾小球病（hyaline glomerulopathy）在B6C3F1小鼠中可作为自发性及/或治疗相关性疾病发生，在F344/N大鼠中则为治疗相关性疾病。其特征为多种肾小球改变，包括细胞外嗜酸性沉积物所致的弥漫性肾小球增大，伴有肾小球毛细血管丛细胞数量减少（Figure 1、Figure 2）。透明样肾小球病必须与淀粉样变性（amyloidosis）相鉴别。有助于将其与淀粉样物质区分开的特殊染色特性包括：过碘酸-雪夫染色（PAS）阴性（Figure 3）、刚果红（Congo red）染色阴性以及Masson三色染色（Masson’s trichrome）阳性。嗜酸性沉积物仅出现于肾小球内，不存在于其他器官。“透明样肾病（hyaline nephropathy）”一词用于描述一种特定的肾小球病变，但并不表明或界定所蓄积物质的成分。需要进行超出常规组织病理学评估范围的特殊研究。

## 诊断与分级建议（NTP 共识，中文）
透明样肾小球病只要存在即应作出诊断并进行分级。分级应基于受累肾小球的数量以及受累肾小球内物质的量。相关链接：肾脏 - 淀粉样变性 肾脏 - 肾小球肾炎 肾脏 - 肾小球硬化

## 英文原文 · Comment
Hyaline glomerulopathy may occur as a spontaneous and/or treatment-related condition in B6C3F1 mice and a treatment-related condition in F344/N rats. It is characterized by several glomerular changes that include diffuse glomerular enlargement by an extracellular eosinophilic deposit accompanied by a reduction in glomerular tuft cellularity ( Figure 1 and Figure 2 ). Hyaline glomerulopathy must be differentiated from amyloidosis. Special staining qualities, which help to distinguish it from amyloid, include period acid-Schiff negativity ( Figure 3 ), Congo red negativity, and Masson’s trichrome positivity. Eosinophilic deposits occur only within the glomerulus and are not present in other organs. The term "hyaline nephropathy" is used to describe a specific glomerular lesion but does not indicate or define the composition of the accumulated material. Special studies outside the scope of routine histopathologic evaluation would be warranted.

## 英文原文 · Recommendation
Hyaline glomerulopathy should be diagnosed and graded whenever present. Grading should be based on the number of glomeruli affected and the amount of material within the affected glomeruli. Related Links: Kidney - Amyloid Kidney - Glomerulonephritis Kidney - Glomerulosclerosis

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_1072.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_1074.jpg

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