# 肾小管嗜双色性空泡性增生(Renal Tubule Hyperplasia Amphophilic Vacuolar) - 器官 / 系统:肾脏 / 泌尿系统(kidney / urinary-system) - NTP 数据编号:ntp-0170 - 规范 URL:https://www.labsmart.cn/ntp/kidney-renal-tubule-hyperplasia-amphophilic-vacuolar.html - 中文图谱总页锚点:https://www.labsmart.cn/ntp-atlas.html#kidney-renal-tubule-hyperplasia-amphophilic-vacuolar - 原始出处:https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/kidney/RenalTubule-HyperplasiaAmphophilic-Vacuolar - 授权:美国联邦政府作品,公有领域;引用请标注 NTP Nonneoplastic Lesion Atlas - 适用说明:仅供科研使用,不用于临床诊断 ## 一句话结论 嗜酸性空泡性(amphophilic-vacuolar,A-V)增生是一种小的增殖性病变,伴有程度不一的嗜酸性胞质染色及细胞内和/或细胞外空泡(Figure 1)。 ## 病变描述(中文) 嗜酸性空泡性(amphophilic-vacuolar,A-V)增生是一种小的增殖性病变,伴有程度不一的嗜酸性胞质染色及细胞内和/或细胞外空泡(Figure 1)。与非典型肾小管增生一样,在A-V增生中,增殖细胞被认为局限于单一肾小管范围内。如果细胞增殖超出单一肾小管的范围,则该病变被认为是肿瘤(腺瘤或癌)。A-V增生被推测为大鼠的一种家族性疾病,可能进展为肿瘤。 ## 诊断与分级建议(NTP 共识,中文) 嗜酸性空泡性增生应诊断为“肾脏,肾小管 - 增生,嗜酸性空泡性”,并给出严重程度分级。相关链接:肾脏 - 肾小管 - 非典型肾小管增生;肾脏 - 肾小管 - 增生,嗜酸性细胞性 ## 英文原文 · Comment Amphophilic-vacuolar (A-V) hyperplasia is a small proliferative lesion associated with variable amphophilic cytoplasmic staining and intra- and/or extracellular vacuoles ( Figure 1 ). As with atypical tubule hyperplasia, in A-V hyperplasia the proliferating cells are considered to be within the confines of a single renal tubule. If the cells proliferate beyond the confines of a single tubule, the lesion is considered a neoplasm (adenoma or carcinoma). A-V hyperplasia has been postulated to be a familial condition in rats, which may progress to tumors. ## 英文原文 · Recommendation Amphophilic-vacuolar hyperplasia should be diagnosed as "Kidney, Renal tubule - Hyperplasia, Amphophilic-vacuolar" and given a severity grade. Related Links: Kidney - Renal Tubule - Atypical Tubule Hyperplasia Kidney - Renal Tubule - Hyperplasia, Oncocytic ## 配图 - https://www.labsmart.cn/ntp-atlas-images/ntp_1112.jpg 整理:北京天融慧通科技有限责任公司(LabSmart)| https://www.labsmart.cn