# 单核细胞性细胞浸润(Infiltration Cellular Mononuclear Cell) - 器官 / 系统:泪腺 / 特殊感觉系统(lacrimal-gland / special-senses-system) - NTP 数据编号:ntp-0321 - 规范 URL:https://www.labsmart.cn/ntp/lacrimal-gland-infiltration-cellular-mononuclear-cell.html - 中文图谱总页锚点:https://www.labsmart.cn/ntp-atlas.html#lacrimal-gland-infiltration-cellular-mononuclear-cell - 原始出处:https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/lacrimal-gland/InfiltrationCellularMononuclearCell - 授权:美国联邦政府作品,公有领域;引用请标注 NTP Nonneoplastic Lesion Atlas - 适用说明:仅供科研使用,不用于临床诊断 ## 一句话结论 散在的、大小不一的单核细胞(通常为淋巴细胞)间质灶在大鼠和小鼠的泪腺中很常见(Figure 1、Figure 2),在老年动物中其发生率和严重程度往往增加。 ## 病变描述(中文) 散在的、大小不一的单核细胞(通常为淋巴细胞)间质灶在大鼠和小鼠的泪腺中很常见(Figure 1、Figure 2),在老年动物中其发生率和严重程度往往增加。此类浸润的发生率和严重程度增加也可作为治疗相关的毒性效应或发生于其他病理状况中。 ## 诊断与分级建议(NTP 共识,中文) 只有当发生率和/或严重程度存在治疗相关差异时,才应对泪腺单核细胞浸润作出诊断并赋予严重程度分级。单核细胞浸润可通过炎症的特征与炎症相区分,如组织破坏、出血、纤维化、水肿以及其他白细胞类型的存在。相关链接:泪腺 - 炎症 ## 英文原文 · Comment Scattered, variably sized interstitial foci of mononuclear cells (usually lymphocytes) are common in the lacrimal glands of rats and mice ( Figure 1 and Figure 2 ), often increasing in incidence and severity in older animals. Increased incidences and severity of such infiltrates can also occur as treatment-related toxic effects or in other pathologic conditions. ## 英文原文 · Recommendation Lacrimal gland mononuclear cell infiltrates should be diagnosed and assigned a severity grade only if there are treatment-related differences in the incidence and/or severity. Mononuclear cell infiltrates can be distinguished from inflammation by features of inflammation such as tissue destruction, hemorrhage, fibrosis, edema, and the presence of other leukocyte types. Related Links: Lacrimal Gland - Inflammation ## 配图 - https://www.labsmart.cn/ntp-atlas-images/ntp_1042.jpg - https://www.labsmart.cn/ntp-atlas-images/ntp_1040.jpg 整理:北京天融慧通科技有限责任公司(LabSmart)| https://www.labsmart.cn