# 胆管囊肿（Bile Duct Cyst）

- 器官 / 系统：肝 / 肝胆系统（liver / hepatobiliary-system）
- NTP 数据编号：ntp-0417
- 规范 URL：https://www.labsmart.cn/ntp/liver-bile-duct-cyst.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#liver-bile-duct-cyst
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/liver/BileDuct-Cyst
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
单房和多房性胆管囊肿（biliary cysts）可在老年大鼠和小鼠中自发发生。

## 病变描述（中文）
单房和多房性胆管囊肿（biliary cysts）可在老年大鼠和小鼠中自发发生。它们可作为单个扩张的胆管结构、多个相邻的扩张胆管结构（Figure 1、Figure 2）或多房性囊肿（Figure 3）出现。胆管囊肿可伴随肝毒性，并可能与外周或基底部的胶原沉积有关（Figure 4）。它们通常由单层扁平或低立方上皮衬覆，几乎没有活跃增殖的证据。与胆管瘤（cholangiomas）不同，它们不压迫相邻的肝实质。

## 诊断与分级建议（NTP 共识，中文）
小的胆管囊肿偶尔可见于未处理的对照大鼠，但更常与处理相关。因此，只要存在就应记录并给予严重程度分级。

## 英文原文 · Comment
Single and multiloculated biliary cysts can occur spontaneously in older rats and mice. They can occur as single dilated biliary structures, multiple adjacent dilated biliary structures ( Figure 1 and Figure 2 ), or a multiloculated cyst ( Figure 3 ). Biliary cysts may accompany hepatic toxicity and may be associated with peripheral or sub-basilar collagen deposition ( Figure 4 ). They are typically lined by a single layer of flattened or low cuboidal epithelium ( Figure 4 ), with little evidence of active proliferation. In contrast to cholangiomas, they do not compress the adjacent hepatic parenchyma.

## 英文原文 · Recommendation
Small biliary cysts may occasionally be seen in untreated rats but are more often associated with treatment. Consequently, they should be documented whenever present and given a severity grade.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0340.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0342.jpg

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