# 胆管增生（Bile Duct Hyperplasia）

- 器官 / 系统：肝 / 肝胆系统（liver / hepatobiliary-system）
- NTP 数据编号：ntp-0418
- 规范 URL：https://www.labsmart.cn/ntp/liver-bile-duct-hyperplasia.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#liver-bile-duct-hyperplasia
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/liver/BileDuct-Hyperplasia
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
胆管增生（bile duct hyperplasia）在亚慢性研究（prechronic studies）中不常见，但属于常见的衰老性病变。

## 病变描述（中文）
胆管增生（bile duct hyperplasia）在亚慢性研究（prechronic studies）中不常见，但属于常见的衰老性病变。在慢性研究中，若各研究组之间在发生率或严重程度上均无差异而偶见胆管增生，则很可能代表背景性病变。该病变在大鼠中比在小鼠中更常见。可能仅累及部分汇管区。胆管增生可伴有胆管周围纤维化（peribiliary fibrosis）。当伴有炎症细胞和/或卵圆细胞增生时，胆管增生可能是毒性损伤的结果。Figure 1、Figure 2 显示单个局灶性增生区域；在该大鼠受检的其他肝脏切片中未见类似病变。此种程度的胆管增生在90天研究的对照大鼠中不常见。

## 诊断与分级建议（NTP 共识，中文）
当胆管增生作为与受试物相关的改变而出现时，或当其程度过度时（如本示例所示），应当予以诊断并赋予严重程度分级。由于胆管增生是常见的年龄相关改变，是否予以诊断的决定将取决于动物的年龄。相关病变，如炎症、纤维化或胆管扩张，若其严重程度足以支持，应当单独诊断。

## 英文原文 · Comment
Bile duct hyperplasia is not commonly seen in prechronic studies but is a common aging lesion. In chronic studies, the occasional occurrence of bile duct hyperplasia in the absence of any differences in incidence or severity among study groups likely represents a background lesion. It is more commonly seen in rats than in mice. Only some portal areas may be affected. Biliary hyperplasia may be associated with peribiliary fibrosis. When accompanied by inflammatory cells and/or oval cell proliferation, bile duct hyperplasia may be the consequence of a toxic insult. Figure 1 and Figure 2 show a single focal area of hyperplasia; similar lesions were not present in the other liver sections examined from this rat. This degree of bile duct hyperplasia is not commonly present in control rats in 90-day studies.

## 英文原文 · Recommendation
Bile duct hyperplasia should be diagnosed and assigned a severity grade whenever present as a treatment-associated change or when excessive, as in this example. Since bile duct hyperplasia is a common age-related change, the decision to diagnose it will depend upon the age of the animal. Associated lesions, such as inflammation, fibrosis, or bile duct dilation, should be diagnosed separately if warranted by the severity of these lesions

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0346.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0347.jpg

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