# 肝膈结节（Hepatodiaphragmatic Nodule）

- 器官 / 系统：肝 / 肝胆系统（liver / hepatobiliary-system）
- NTP 数据编号：ntp-0416
- 规范 URL：https://www.labsmart.cn/ntp/liver-hepatodiaphragmatic-nodule.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#liver-hepatodiaphragmatic-nodule
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/liver/HepatodiaphragmaticNodule
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
肝中叶一部分突入膈肌是各年龄段大鼠的先天性病变，小鼠中偶见。该异常同时累及肝脏和膈肌。

## 病变描述（中文）
肝中叶一部分突入膈肌是各年龄段大鼠的先天性病变，小鼠中偶见。该异常同时累及肝脏和膈肌。肝脏突出部分并不穿透膈肌，而是被膈肌薄层纤维腱膜覆盖。这些结节通常边界不清，具有正常的肝脏结构（Figure 1）。结节内肝细胞核可能含有线性染色质排列，类似于Anitschkow肌细胞中所见的核轮廓（Figure 2、Figure 3）。

## 诊断与分级建议（NTP 共识，中文）
尽管这是一种偶发且不受处理影响的背景病变，但它是先天性病变，只要存在就应诊断。这些病变不应进行分级。

## 英文原文 · Comment
Protrusion of a portion of the median lobe into the diaphragm represents a congenital lesion in rats of any age and is occasionally seen in mice. This anomaly involves both the liver and the diaphragm. The protrusion of the liver does not penetrate the diaphragm but is covered by the thin fibrous tendon of the diaphragm. These nodules typically are not well demarcated and have normal hepatic architecture ( Figure 1 ). Hepatocyte nuclei within the nodule may contain linear chromatin arrangements resembling nuclear profiles seen in Anitschkow myocytes ( Figure 2 and Figure 3 ).

## 英文原文 · Recommendation
Although this is a background lesion that occurs sporadically and is not affected by treatment, it is a congenital lesion and should be diagnosed whenever present. These lesions should not be graded.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0366.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0370.jpg

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