# 肝细胞内红细胞（Intrahepatocellular Erythrocytes）

- 器官 / 系统：肝 / 肝胆系统（liver / hepatobiliary-system）
- NTP 数据编号：ntp-0408
- 规范 URL：https://www.labsmart.cn/ntp/liver-intrahepatocellular-erythrocytes.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#liver-intrahepatocellular-erythrocytes
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/liver/IntrahepatocellularErythrocytes
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
肝细胞内红细胞（intrahepatocellular erythrocytes）不常见，在老龄小鼠中可作为自发性改变出现。

## 病变描述（中文）
肝细胞内红细胞（intrahepatocellular erythrocytes）不常见，在老龄小鼠中可作为自发性改变出现。然而，在一些NTP研究中，该改变似乎因受试物处理而加重。在低倍镜下，它可能与血管扩张（angiectasis）相混淆；在高倍镜下，增大的肝细胞被大量红细胞填充并扩张。关于该改变由红细胞吞噬作用（erythrophagocytosis）或伸入运动（emperipolesis）所致的推测尚未经超微结构研究证实。

## 诊断与分级建议（NTP 共识，中文）
肝细胞内红细胞只要存在就应记录，病理描述中应包含该改变范围的描述。肝实质中任何相关的退行性或其他改变，若根据这些病变的严重程度有必要，应单独诊断；否则，应在病理描述中提及。

## 英文原文 · Comment
Intrahepatocellular erythrocytes are uncommon and may be seen as a spontaneous change in aging mice. However, in some NTP studies, this change appears to have been exacerbated by treatment. At low magnification, it may be confused with angiectasis; at higher magnification, enlarged hepatocytes are filled and expanded by numerous erythrocytes. Speculation that this change occurs by erythrophagocytosis or emperipolesis has not been confirmed by ultrastructural studies.

## 英文原文 · Recommendation
Intrahepatocellular erythrocytes should be documented whenever present, and the pathology narrative should include a description of the extent of the change. Any associated degenerative or other changes in the hepatic parenchyma should be diagnosed separately if warranted by the severity of these lesions; otherwise, they should be mentioned in the pathology narrative.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0367.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0373.jpg

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