# 肥大细胞增生(Hyperplasia Mast Cell) - 器官 / 系统:淋巴结 / 免疫系统(lymph-node / immune-system) - NTP 数据编号:ntp-0011 - 规范 URL:https://www.labsmart.cn/ntp/lymph-node-hyperplasia-mast-cell.html - 中文图谱总页锚点:https://www.labsmart.cn/ntp-atlas.html#lymph-node-hyperplasia-mast-cell - 原始出处:https://ntp.niehs.nih.gov/atlas/nnl/immune-system/lymph-node/HyperplasiaMastCell - 授权:美国联邦政府作品,公有领域;引用请标注 NTP Nonneoplastic Lesion Atlas - 适用说明:仅供科研使用,不用于临床诊断 ## 一句话结论 肥大细胞增生(mast cell hyperplasia)是指淋巴结内肥大细胞数量超过正常水平(即同期对照组)。 ## 病变描述(中文) 肥大细胞增生(mast cell hyperplasia)是指淋巴结内肥大细胞数量超过正常水平(即同期对照组)。肥大细胞可在淋巴结窦内和实质内以单个细胞和/或细胞簇的形式聚集(Figure 1、Figure 2,箭头)。肥大细胞通过活化和从抗原接触部位迁移至引流淋巴结,参与初级免疫反应的诱导,在引流淋巴结中表达调节T细胞募集的趋化因子。Giemsa染色或甲苯胺蓝染色可特异性识别呈异染性的肥大细胞颗粒。 ## 诊断与分级建议(NTP 共识,中文) 肥大细胞增生一旦出现即应作出诊断并进行分级。 ## 英文原文 · Comment Mast cell hyperplasia is an increase in the number of mast cells above that normally found in lymph nodes (i.e., concurrent controls). Mast cells may accumulate in lymph nodes as individual and/or clusters of cells within the nodal sinuses and parenchyma ( Figure 1 and Figure 2 , arrows). Mast cells contribute to the induction of the primary immune response by activation and migration from the site of antigen encounter to draining lymph nodes, where they express chemokines that regulate T-cell recruitment. Giemsa or toluidine blue can specifically identify the metachromic mast cell granules. ## 英文原文 · Recommendation Mast cell hyperplasia should be diagnosed and graded whenever present. ## 配图 - https://www.labsmart.cn/ntp-atlas-images/ntp_0393.jpg - https://www.labsmart.cn/ntp-atlas-images/ntp_0401.jpg 整理:北京天融慧通科技有限责任公司(LabSmart)| https://www.labsmart.cn