# 上皮细胞透明滴蓄积（Epithelium Accumulation Hyaline Droplet）

- 器官 / 系统：鼻 / 呼吸系统（nose / respiratory-system）
- NTP 数据编号：ntp-0126
- 规范 URL：https://www.labsmart.cn/ntp/nose-epithelium-accumulation-hyaline-droplet.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#nose-epithelium-accumulation-hyaline-droplet
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/nose/Epithelium-AccumulationHyalineDroplet
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
透明滴（hyaline droplet）（Figure 1、Figure 2、Figure 3、Figure 4）在小鼠和大鼠中均可见到，其特征为嗜酸性、均质、球状、玻璃样物质在呼吸道上皮细胞、嗅上皮支持细胞（sustentacular cell）或浆液黏液腺上皮细胞的细胞质内蓄积。

## 病变描述（中文）
透明滴（hyaline droplet）（Figure 1、Figure 2、Figure 3、Figure 4）在小鼠和大鼠中均可见到，其特征为嗜酸性、均质、球状、玻璃样物质在呼吸道上皮细胞、嗅上皮支持细胞（sustentacular cell）或浆液黏液腺上皮细胞的细胞质内蓄积。这些滴状物可位于核下或核上，并可使细胞变形。它们偶尔伴有细胞内或细胞外嗜酸性结晶。嗅上皮与呼吸道上皮的交界处是观察到此变化的非常常见部位，尤其是在 II 级切片的鼻中隔和背侧鼻道。该物质尚未被明确鉴定，但据报道可与羧酸酯酶（carboxylesterase）抗体及 Ym2 蛋白的 Ym1 序列抗体发生反应。在对照大鼠和小鼠中可见少量此类滴状物，并随年龄增长而增多。滴状物的数量和大小可因处理而加重，但其不被视为退行性改变。

## 诊断与分级建议（NTP 共识，中文）
由于透明滴可见于对照动物，将其诊断为病变（“蓄积，透明滴”）一般应代表滴状物的大小和/或数量相对于对照有所增加。如果对照动物与处理动物之间没有差异，则无需诊断此变化。当作出诊断时，应赋予该病变严重程度分级，并应将上皮类型作为部位修饰词纳入诊断。由于此不被视为退行性改变，任何并发的细胞退行性变均应单独诊断并分级。

## 英文原文 · Comment
The presence of hyaline droplets ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ), which is seen in both mice and rats, is characterized by the accumulation of eosinophilic, homogeneous, globular, hyaline material in the cytoplasm of cells of the respiratory epithelium, sustentacular cells of the olfactory epithelium, or epithelial cells of seromucous glands. The droplets may be subnuclear or supranuclear and can distort the cells. They are occasionally accompanied by intra- or extracellular eosinophilic crystals. The junction of the olfactory and respiratory epithelia is a very common site to see this change, particularly on the nasal septum of the level II section and in the dorsal meatus. The material has not been definitively identified, but it has been reported to react to antibodies for carboxylesterase and the Ym1 sequence of the Ym2 protein. The droplets are found in low numbers in control rats and mice and increase with age. The number and size of droplets can be exacerbated by treatment, but it is not considered a degenerative change.

## 英文原文 · Recommendation
Because the hyaline droplets can be found in control animals, diagnosis of this as a lesion ("Accumulation, Hyaline droplet") should generally represent an increase in the size and/or number of droplets relative to controls. If there is no difference between the control and treated animals, this change need not be diagnosed. When diagnosed this lesion should be assigned a severity grade, and the epithelial type should be included in the diagnosis as the site modifier. Since this is not considered a degenerative change, any concurrent cellular degeneration should be diagnosed and graded separately.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0901.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0902.jpg

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