# 上皮纤维化（Epithelium Fibrosis）

- 器官 / 系统：鼻 / 呼吸系统（nose / respiratory-system）
- NTP 数据编号：ntp-0125
- 规范 URL：https://www.labsmart.cn/ntp/nose-epithelium-fibrosis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#nose-epithelium-fibrosis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/nose/Epithelium-Fibrosis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
纤维化在显微镜下表现为纤维结缔组织数量增加，取代或扩张正常结构。由于纤维化通常是对严重组织损伤的反应，因此常与炎症和/或坏死相关。

## 病变描述（中文）
纤维化在显微镜下表现为纤维结缔组织数量增加，取代或扩张正常结构。由于纤维化通常是对严重组织损伤的反应，因此常与炎症和/或坏死相关。鼻部固有层中的纤维化（Figure 1；与Figure 2所示的对照相比）不常见。

## 诊断与分级建议（NTP 共识，中文）
纤维化在鼻腔中是一种不常见的病变，观察到时应予以诊断并赋予严重程度分级。与炎症一样，与纤维化相关的上皮细胞类型应作为部位修饰词记录。其他病变，如上述炎症和增生，应单独诊断。

## 英文原文 · Comment
Fibrosis appears microscopically as an increase in the amount of fibrous connective tissue that either replaces or expands normal structures. Because it is often a response to severe tissue damage, fibrosis is often associated with inflammation and/or necrosis. Fibrosis in the lamina propria of the nose ( Figure 1 ; compare with control shown in Figure 2 ) is uncommon.

## 英文原文 · Recommendation
Fibrosis is an uncommon lesion in the nasal cavity and should be diagnosed and assigned a severity grade whenever it is observed. As with inflammation, the epithelial cell type associated with the fibrosis should be recorded as a site modifier. Other lesions, such as the inflammation and hyperplasia noted above, should be diagnosed separately.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0907.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0903.jpg

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