# 嗅上皮萎缩（Olfactory Epithelium Atrophy）

- 器官 / 系统：鼻 / 呼吸系统（nose / respiratory-system）
- NTP 数据编号：ntp-0135
- 规范 URL：https://www.labsmart.cn/ntp/nose-olfactory-epithelium-atrophy.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#nose-olfactory-epithelium-atrophy
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/nose/OlfactoryEpithelium-Atrophy
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
嗅上皮萎缩（olfactory epithelial atrophy）是指上皮细胞丢失，导致上皮变薄、细胞数量减少（Figure 1、Figure 2、Figure 3、Figure 4）。

## 病变描述（中文）
嗅上皮萎缩（olfactory epithelial atrophy）是指上皮细胞丢失，导致上皮变薄、细胞数量减少（Figure 1、Figure 2、Figure 3、Figure 4）。上皮表面可能覆盖立方至柱状无纤毛上皮。它通常是鼻部一系列变化的一部分，这些变化包括炎症、变性或坏死，以及呼吸上皮或鳞状上皮化生。事实上，嗅上皮萎缩往往是嗅上皮变性或坏死的最终结果。下方的鼻甲骨也可能发生萎缩。

## 诊断与分级建议（NTP 共识，中文）
当病变与其他嗅上皮变化（如变性、坏死或呼吸上皮化生）明显分开时，应诊断嗅上皮萎缩。炎症、嗅神经萎缩和鼻甲萎缩可能伴随上皮变化出现，应分别诊断（见 Nose - Inflammation；Nose - Nerve - Atrophy；和 Nose - Turbinate - Atrophy）。相关链接：Nose - Inflammation Nose - Nerve - Atrophy Nose - Turbinate - Atrophy

## 英文原文 · Comment
Olfactory epithelial atrophy is a loss of cells from the epithelium, resulting in a thinner and less cellular epithelium ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ). The epithelial surface may be covered with cuboidal to columnar nonciliated epithelium. It is often part of a spectrum of changes in the nose that includes inflammation, degeneration or necrosis, and respiratory or squamous metaplasia. In fact, olfactory epithelial atrophy is often the end result of degeneration or necrosis of the olfactory epithelium. The underlying turbinate bone may also be atrophic.

## 英文原文 · Recommendation
Olfactory epithelial atrophy should be diagnosed when a lesion is clearly separate from other olfactory epithelial changes such as degeneration, necrosis, or respiratory epithelial metaplasia. Inflammation, olfactory nerve atrophy, and turbinate atrophy may accompany the epithelial changes and should be diagnosed separately (see Nose - Inflammation ; Nose - Nerve - Atrophy ; and Nose - Turbinate - Atrophy ). Related Links: Nose - Inflammation Nose - Nerve - Atrophy Nose - Turbinate - Atrophy

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0926.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0930.jpg

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