# 淀粉样物质（Amyloid）

- 器官 / 系统：卵巢 / 雌性生殖系统（ovary / reproductive-system-female）
- NTP 数据编号：ntp-0514
- 规范 URL：https://www.labsmart.cn/ntp/ovary-amyloid.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#ovary-amyloid
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/ovary/Amyloid
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
卵巢中的淀粉样物质（amyloid）以均质、无细胞、嗜酸性玻璃样物质的沉积为特征（Figure 1、Figure 2、Figure 3、Figure 4）。

## 病变描述（中文）
卵巢中的淀粉样物质（amyloid）以均质、无细胞、嗜酸性玻璃样物质的沉积为特征（Figure 1、Figure 2、Figure 3、Figure 4）。沉积物主要发生于黄体（corpora lutea）及中等大小动脉的管壁（Figure 2）。在较严重的病例中，淀粉样物质沉积几乎取代了全部实质组织（Figure 3、Figure 4）。衰老过程中的淀粉样物质沉积在若干小鼠品系中发生率增高，如 Cd-1、A、SJL 或 C57BL；然而，在 B6C3F1 小鼠和大鼠中不常见。淀粉样变性（amyloidosis）是一种由错误折叠蛋白质的组织沉积所致的复杂病变，最常见的类型为免疫球蛋白轻链蛋白。淀粉样变性的严重程度和发生率增高可能与衰老和/或慢性炎症状态（如溃疡性皮炎）相关。淀粉样物质经刚果红（Congo red）染色后，在偏振光下呈绿色双折射。

## 诊断与分级建议（NTP 共识，中文）
卵巢——淀粉样物质一旦出现即应作出诊断并分级。病理学家应在叙述中描述该病变，并评论淀粉样物质如何影响研究结果。继发于淀粉样物质沉积的病变不应单独诊断，除非其严重程度足以支持单独诊断，但应在病理学叙述中予以描述。

## 英文原文 · Comment
Amyloid in the ovary is characterized the deposition of homogeneous, acellular, eosinophilic glassy material ( Figure 1 , Figure 2 , Figure 3 and Figure 4 ). Deposits occur primarily in the corpora lutea and in the walls of medium-sized arteries ( Figure 2 ). In more severe cases, amyloid deposits replace almost all of the parenchymal tissue ( Figure 3 and Figure 4 ). Deposition of amyloid during senescence occurs at increased incidences in several strains of mice, such as Cd-1, A, SJL, or C57BL; however, it is uncommon in B6C3F1 mice and rats. Amyloidosis is a complex condition due to tissue deposition of misfolded proteins, with the most common type being immunoglobulin light-chain proteins. Increased severity and incidence of amyloidosis may occur in association with aging and/or with chronic inflammatory conditions such as ulcerative dermatitis. Amyloid shows a green birefringence under polarized light when stained with Congo red dye.

## 英文原文 · Recommendation
Ovary - Amyloid should be diagnosed and graded whenever present. The pathologist should describe this lesion in the narrative and comment on how the amyloid affects the results of the study. Lesions occurring secondary to amyloid deposition should not be diagnosed separately, unless warranted by severity, but should be described in the pathology narrative.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0610.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0615.jpg

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