# 支持细胞样增生（Hyperplasia Sertoliform）

- 器官 / 系统：卵巢 / 雌性生殖系统（ovary / reproductive-system-female）
- NTP 数据编号：ntp-0513
- 规范 URL：https://www.labsmart.cn/ntp/ovary-hyperplasia-sertoliform.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#ovary-hyperplasia-sertoliform
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/ovary/HyperplasiaSertoliform
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
卵巢支持细胞增生的关键特征是细胞在组织学上类似于睾丸的支持细胞，并且这些增生性病变常发生于卵巢门区域（Figure 1）。

## 病变描述（中文）
卵巢支持细胞增生的关键特征是细胞在组织学上类似于睾丸的支持细胞，并且这些增生性病变常发生于卵巢门区域（Figure 1）。其特征为类似生精小管的管状结构，管壁衬覆细胞，细胞核位于基底部，胞质丰富、呈淡嗜酸性、空泡化并延伸至管腔（Figure 2）。有时可出现由支持细胞局灶性巢状聚集构成的区域，而无明显的管状结构。支持细胞增生通常为局灶性（focal）病变，大小小于或等于一个黄体；无细胞异型性，也无压迫或包膜。支持细胞增生被认为起源于萎缩卵巢中的间质细胞。该病变与衰老相关，但也可能由化学物质诱导。支持细胞增生必须与无性细胞瘤（dysgerminoma）和支持细胞瘤相鉴别。支持细胞瘤的大小大于一个黄体；存在对邻近组织的压迫，并可能出现一定程度的细胞异型性。无性细胞瘤在大鼠中未见报道，在小鼠中为罕见肿瘤；其组织学表现为大片圆形、未分化细胞。

## 诊断与分级建议（NTP 共识，中文）
卵巢——增生，支持细胞样（Hyperplasia, Sertoliform）只要存在即应作出诊断并赋予严重程度分级。

## 英文原文 · Comment
The key features of Sertoli cell hyperplasia in the ovary are that the cells resemble their testicular counterpart histologically and that these proliferative lesions often arise in the region of the hilus ( Figure 1 ). They are characterized by seminiferous-like tubules lined by cells with basally located nuclei and abundant, faintly eosinophilic, vacuolated cytoplasm extending into the lumen ( Figure 2 ). Sometimes there may be areas with focal nests of Sertoli cells without obvious tubular structures. Sertoli cell hyperplasia is typically a focal lesion smaller than or equal to the size of a corpus luteum; there is no cellular atypia, and neither compression nor capsules are present. Sertoli cell hyperplasia is thought to be derived from stromal cells in atrophic ovaries. This finding is associated with aging but may also be induced by chemicals. Sertoli cell hyperplasia must be differentiated from dysgerminoma and Sertoli cell tumor. Sertoli cell tumors are larger than the size of a corpus luteum; there is compression of adjacent tissue, and some cellular atypia may be present. Dysgerminomas are not reported in the rat and are a rare tumor in mice; the histologic appearance is of sheets of large, round, undifferentiated cells.

## 英文原文 · Recommendation
Ovary - Hyperplasia, Sertoliform should be diagnosed and assigned a severity grade whenever present.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0633.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0635.jpg

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