# 间质细胞增生（Interstitial Cell Hyperplasia）

- 器官 / 系统：卵巢 / 雌性生殖系统（ovary / reproductive-system-female）
- NTP 数据编号：ntp-0524
- 规范 URL：https://www.labsmart.cn/ntp/ovary-interstitial-cell-hyperplasia.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#ovary-interstitial-cell-hyperplasia
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/ovary/InterstitialCell-Hyperplasia
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
通常，在间质细胞增生（interstitial cell hyperplasia）中，许多大小不一的淡染细胞簇散布于处于不同发育阶段的数个卵泡之间，包括大的闭锁卵泡、成熟黄体、色素沉着区域和充血血管（Figure 1）。

## 病变描述（中文）
通常，在间质细胞增生（interstitial cell hyperplasia）中，许多大小不一的淡染细胞簇散布于处于不同发育阶段的数个卵泡之间，包括大的闭锁卵泡、成熟黄体、色素沉着区域和充血血管（Figure 1）。增生的间质细胞索和巢由大的多面体细胞组成，胞质呈淡嗜酸性颗粒状，核位于中央（Figure 2）。卵巢间质细胞增生是间质腺细胞成分的非肿瘤性增殖，这些细胞成分来源于闭锁卵泡、黄体或卵巢基质细胞。这是大鼠和小鼠常见的衰老性改变。它也可能由某些化学物质处理诱导，如促性腺激素和某些有机磷化合物。

## 诊断与分级建议（NTP 共识，中文）
卵巢，间质细胞 - 增生：只要存在就应诊断并分级。

## 英文原文 · Comment
Typically in interstitial cell hyperplasia many variably sized clusters of pale-staining cells are interspersed among several follicles in various stages of development, including large atretic follicles, mature corpora lutea, areas of pigment deposition, and congested blood vessels ( Figure 1 ). Cords and nests of hyperplastic interstitial cells are composed of large polyhedral cells with pale eosinophilic granular cytoplasm and central nuclei ( Figure 2 ). Ovarian interstitial cell hyperplasia is a nonneoplastic proliferation of cellular components of the interstitial gland, derived from atretic follicles, corpora lutea, or ovarian stromal cells. This is a common aging change in rats and mice. It may also be induced by treatment with certain chemicals, such as gonadotropins and some organophosphate compounds.

## 英文原文 · Recommendation
Ovary, Interstitial cell - Hyperplasia should be diagnosed and graded whenever present.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0637.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0638.jpg

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