# 坏死（Necrosis）

- 器官 / 系统：卵巢 / 雌性生殖系统（ovary / reproductive-system-female）
- NTP 数据编号：ntp-0511
- 规范 URL：https://www.labsmart.cn/ntp/ovary-necrosis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#ovary-necrosis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/ovary/Necrosis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
卵巢——坏死可能表现为边界清楚、无包膜的区域，中央由无定形坏死细胞碎片构成，外周有中等数量的以单核炎症细胞为主的炎症细胞浸润（Figure 1、Figure 2、Figure 3）。

## 病变描述（中文）
卵巢——坏死可能表现为边界清楚、无包膜的区域，中央由无定形坏死细胞碎片构成，外周有中等数量的以单核炎症细胞为主的炎症细胞浸润（Figure 1、Figure 2、Figure 3）。卵巢中坏死的特征与其他组织相同，包括核固缩和/或核碎裂、胞质嗜酸性增强以及细胞肿胀或皱缩。

## 诊断与分级建议（NTP 共识，中文）
卵巢——当坏死为原发性病变时，应作出诊断并分级。若坏死继发于其他病变（如炎症），除非严重程度确有必要，否则不应单独诊断，但应在病理学描述中予以描述。被认为继发于坏死的病变（如炎症或出血），除非严重程度确有必要，否则不应单独诊断。闭锁卵泡或退化黄体中的凋亡细胞不应诊断为坏死。

## 英文原文 · Comment
Ovary - Necrosis may be present is a well-circumscribed, unencapsulated area composed of amorphous necrotic cellular debris centrally and moderate numbers of mainly mononuclear inflammatory cells peripherally ( Figure 1 , Figure 2 and Figure 3 ). The features of necrosis in the ovary, as in other tissues, include nuclear pyknosis and/or karyorrhexis, cytoplasmic eosinophilia, and cellular swelling or shrinkage.

## 英文原文 · Recommendation
Ovary - Necrosis should be diagnosed and graded when it is a primary lesion. If the necrosis is secondary to another lesion, such as inflammation, it should not be diagnosed separately unless warranted by severity but should be described in the pathology narrative. Lesions that are considered secondary to the necrosis, such as inflammation or hemorrhage, should not be diagnosed separately unless warranted by severity. Apoptotic cells in atretic follicles or regressing corpora lutea should not be diagnosed as necrosis.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0646.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0648.jpg

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