# 远侧部萎缩（Pars Distalis Atrophy）

- 器官 / 系统：垂体 / 内分泌系统（pituitary-gland / endocrine-system）
- NTP 数据编号：ntp-0051
- 规范 URL：https://www.labsmart.cn/ntp/pituitary-gland-pars-distalis-atrophy.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#pituitary-gland-pars-distalis-atrophy
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/pituitary-gland/ParsDistalis-Atrophy
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
远侧部（pars distalis）萎缩可作为缺血所致坏死的后遗症发生，和/或由占位性病变对垂体的压迫引起。

## 病变描述（中文）
远侧部（pars distalis）萎缩可作为缺血所致坏死的后遗症发生，和/或由占位性病变对垂体的压迫引起。后者更为常见。萎缩组织内的巨噬细胞内可能存在黄褐色色素（含铁血黄素）（Figure 1、Figure 2、Figure 3、Figure 4）。远侧部的小部分区域可能受累较轻或不受累。相比之下，垂体神经纤维中断很可能导致垂体后叶萎缩。萎缩最常见于远侧部，但也可能累及中间部（pars intermedia）和神经部（pars nervosa）。

## 诊断与分级建议（NTP 共识，中文）
垂体萎缩只要存在即应诊断并分级。受累区域应作为部位修饰词纳入诊断（例如，Pituitary, Pars distalis - Atrophy）。若受累区域超过一个，可省略部位修饰词，并在病理描述中注明受累部位。病理描述还可描述形态学特征（包括是否存在载色素巨噬细胞）及病变范围。

## 英文原文 · Comment
Atrophy of the pars distalis can occur as a sequela of necrosis secondary to ischemia and/or from compression on the pituitary by a space occupying mass. The latter is more common. Yellow-brown pigment (hemosiderin) may be present within macrophages in the atrophic tissue ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ). Small portions of the pars distalis may be spared. In contrast, interruption of hypophyseal nerve fibers would likely result in atrophy of the posterior lobe of the pituitary. Atrophy is most common in the pars distalis but may also affect the pars intermedia and the pars nervosa.

## 英文原文 · Recommendation
Atrophy of the pituitary should be diagnosed and graded whenever present. The area affected should be included in the diagnosis as a site modifier (e.g., Pituitary, Pars distalis - Atrophy). If more than one area is affected, the site modifier may be omitted and the affected sites noted in the pathology narrative. The pathology narrative can also describe the morphologic features (including the presence of pigment laden macrophages) and extent of the change.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0283.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0287.jpg

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