坏死Necrosis · 包皮腺 · 雄性生殖系统 · NTP ntp-0451
诊断要点：坏死应记录并分级，若因化学物给药而加重，则应在病理学叙述中予以记录。若两个腺体均受累，诊断应限定为双侧（bilateral），严重程度基于受累更严重的腺体。
病变描述
包皮腺坏死表现为细胞细节丧失、嗜酸性粒细胞增多（hypereosinophilia），以及被细胞碎片和核碎裂碎片所取代（星号，Figure 1、Figure 2）。坏死区域通常与邻近未受累的腺体界限分明（Figure 1、Figure 2）。坏死碎片应仔细与正常情况下在导管内观察到的嗜酸性角化物质相鉴别。坏死可为局灶性（focal）或多灶性（multifocal），可能累及一个或两个腺体，并可能与炎症相关。在 Figure 1、Figure 2 中，坏死是主要反应，不伴有炎症。
诊断与分级建议（NTP 共识）
坏死应记录并分级，若因化学物给药而加重，则应在病理学叙述中予以记录。若两个腺体均受累，诊断应限定为双侧（bilateral），严重程度基于受累更严重的腺体。当坏死作为炎症的继发反应出现时，除非异常严重，否则无需诊断，但可在病理学叙述中提及。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Necrosis of preputial gland consists of loss of cellular detail, hypereosinophilia, and replacement by cellular and karyorrhectic debris (asterisk, Figure 1 and Figure 2 ). The necrotic area is often distinct from the adjacent unaffected gland ( Figure 1 and Figure 2 ). The necrotic debris should be carefully differentiated from the hypereosinophilic keratinous material normally observed within ducts. Necrosis can be focal or multifocal, may involve one or both glands, and may be associated with inflammation. In Figure 1 and Figure 2 , the necrosis is the major response without associated inflammation.
Recommendation：
Necrosis should be recorded and graded, and if exacerbated by chemical administration, this should be documented in the pathology narrative. If both glands are affected, the diagnosis should be qualified as bilateral and the severity based on the more severely affected gland. When necrosis is present as a secondary response to inflammation, it need not be diagnosed unless unusually severe but may be mentioned in the pathology narrative.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/preputial-gland/Necrosis
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Necrosis (preputial-gland). LabSmart 中文版：
https://www.labsmart.cn/ntp/preputial-gland-necrosis.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#preputial-gland-necrosis