# 腺泡扩张（Acinus Dilation）

- 器官 / 系统：前列腺 / 雄性生殖系统（prostate / reproductive-system-male）
- NTP 数据编号：ntp-0449
- 规范 URL：https://www.labsmart.cn/ntp/prostate-acinus-dilation.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#prostate-acinus-dilation
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/prostate/Acinus-Dilation
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
前列腺扩张（ectasia）或扩张（dilation）的特征是腺泡有时因分泌物质而膨胀，并被变薄的上皮细胞所衬覆（Figure 1、Figure 2、Figure 3、Figure 4）。

## 病变描述（中文）
前列腺扩张（ectasia）或扩张（dilation）的特征是腺泡有时因分泌物质而膨胀，并被变薄的上皮细胞所衬覆（Figure 1、Figure 2、Figure 3、Figure 4）。可能出现明显的腺泡增大，尤其是伴有周围未受累腺泡和实质的显著受压，扩张呈囊性外观（Figure 3、Figure 4）。受累腺泡的分泌物质可表现为接近正常的染色反应（Figure 1、Figure 2），也可如 Figure 3、Figure 4 中所示的静息腺体那样染色不良。受累腺泡可见于任何叶，并可累及叶的一部分或整个叶。这很可能是与年龄相关的病变，并可能与间质炎症相关。

## 诊断与分级建议（NTP 共识，中文）
在毒性研究的前列腺组织病理学评价中，前列腺扩张应被记录并给予严重程度分级。如有可能，应确定受累的叶，并在组织标识中注明（例如，prostate, dorsolateral lobe, acinus - dilation, 中度（moderate））。如果成对的叶均受累，诊断应限定为双侧性（双侧（bilateral）），严重程度基于受累更严重的腺体。

## 英文原文 · Comment
Ectasia or dilation of the prostate is characterized by acini that are sometimes distended with secretory material and lined by attenuated epithelial cells ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ). There may be marked acinar enlargement, particularly with significant compression of surrounding unaffected acini and parenchyma, with the dilation appearing cystic ( Figure 3 and Figure 4 ). Affected acinar secretory material can exhibit either a near normal staining reaction ( Figure 1 and Figure 2 ) or can be poorly stained as in the quiescent gland shown in Figure 3 and Figure 4 . Affected acini can be observed in any lobe and can involve either a part or the entire lobe. This is likely an age-related lesion and may be associated with interstitial inflammation.

## 英文原文 · Recommendation
Prostatic dilatation should be recorded and given a severity grade during histopathologic evaluation of prostate from toxicity studies. The affected lobe(s) should be identified if possible and indicated in the tissue identification (e.g., prostate, dorsolateral lobe, acinus - dilation, moderate). If paired lobes are both affected, the diagnosis should be qualified as bilateral, with severity based on the more severely affected gland.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0777.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0781.jpg

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