# 腺泡分泌改变（含凝结物）（Acinus Secretoryalteration(concretions)）

- 器官 / 系统：前列腺 / 雄性生殖系统（prostate / reproductive-system-male）
- NTP 数据编号：ntp-0447
- 规范 URL：https://www.labsmart.cn/ntp/prostate-acinus-secretoryalteration-concretions.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#prostate-acinus-secretoryalteration-concretions
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/prostate/Acinus-Secretoryalteration%28concretions%29
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
随着啮齿类动物年龄增长，生殖活动减少，前列腺腺泡（prostatic acini）内的分泌物质发生改变。

## 病变描述（中文）
随着啮齿类动物年龄增长，生殖活动减少，前列腺腺泡（prostatic acini）内的分泌物质发生改变。这种改变可以是弥漫性的，也可以局限于任一叶，但以腹叶（ventral lobe）多见。组织学表现多样，从玻璃样团块，到细颗粒或粗颗粒状分泌物，再到深嗜碱性颗粒状沉淀物（箭头，Figure 2），常呈混合性表现（Figure 1、Figure 2）。腺泡上皮衬里通常为低立方状至扁平状。发生改变的分泌物有时称为凝结物（concretions），本质上是变性的分泌蛋白和细胞碎片，有时伴有矿化。

## 诊断与分级建议（NTP 共识，中文）
分泌改变在慢性研究中常见，除非存在明显的与处理相关的影响，通常不予记录。然而，在持续时间不超过90天的亚慢性研究中，该改变并不常见，若有任何提示处理直接或间接作用的迹象，则应在这些研究中作出诊断。如有可能，应确定受累的叶，并在组织标识中注明。任何诊断均应给出严重程度分级；若成对叶均受累，诊断应限定为双侧性（双侧（bilateral）），严重程度以受累较重的一侧叶为准。

## 英文原文 · Comment
As rodents age, there is decreased reproductive activity and alterations of secretory material in prostatic acini. This can be generalized or localized within any lobe, but with a predilection for the ventral lobe. The histologic appearance varies from hyaline masses, to finely or coarsely granulated secretion, to deeply basophilic granular precipitates (arrows, Figure 2 ), often appearing as a mixture ( Figure 1 and Figure 2 ). The acinar epithelial lining typically is low cuboidal to flattened. The altered secretion, sometimes referred to as concretions, is essentially denatured secretory protein and cellular debris, sometimes with mineralization.

## 英文原文 · Recommendation
Secretory alteration is common in chronic studies and is typically not documented unless there is an obvious treatment-related effect. However, it is not common in prechronic studies up to 90 days in duration and should be diagnosed in those studies if there is any indication of a direct or indirect effect of treatment. The affected lobe(s) should be identified if possible and indicated in the tissue identification. Any diagnosis should be given a severity grade, and if paired lobes are affected, the diagnosis should be qualified as bilateral, with severity based on the more severely affected lobe.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0780.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0783.jpg

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