# 上皮变性（Epithelium Degeneration）

- 器官 / 系统：前列腺 / 雄性生殖系统（prostate / reproductive-system-male）
- NTP 数据编号：ntp-0442
- 规范 URL：https://www.labsmart.cn/ntp/prostate-epithelium-degeneration.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#prostate-epithelium-degeneration
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/prostate/Epithelium-Degeneration
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
上皮变性（epithelial degeneration）的特征是增大的腺泡上皮细胞胞质呈颗粒状至泡沫状改变，这些细胞形成单层衬覆层（Figure 1、Figure 2），或脱落并阻塞腺泡腔（Figure 3）。

## 病变描述（中文）
上皮变性（epithelial degeneration）的特征是增大的腺泡上皮细胞胞质呈颗粒状至泡沫状改变，这些细胞形成单层衬覆层（Figure 1、Figure 2），或脱落并阻塞腺泡腔（Figure 3）。受累细胞增大，胞质富含细颗粒状物质，可发生破裂和解体。上皮变性可为局灶性（focal）或多灶性（multifocal）。该病变可见于任何叶，但最常见于腹侧叶。上皮变性在老龄前列腺中是相当常见的观察所见。该病变可伴有炎性浸润。

## 诊断与分级建议（NTP 共识，中文）
存在时，该病变应当诊断并分级。化学物质所致的加重值得在病理学叙述中记录。如有可能，应确定受累的叶，并在组织标识中指明。若成对的叶均受累，诊断应指明该变化为双侧性，严重程度依据受累更严重的叶判定。

## 英文原文 · Comment
Epithelial degeneration is characterized by granular to foamy cytoplasm alteration of enlarged acinar epithelial cells that form a single lining layer ( Figure 1 and Figure 2 ) or exfoliate and occlude the lumen of acini ( Figure 3 ). Affected cells are enlarged with abundant finely granular cytoplasm and may rupture and disintegrate. Epithelial degeneration can be focal or multifocal. The lesion can be observed in any lobe, but is most commonly found in the ventral lobe. Epithelial degeneration is a fairly common observation in the aging prostate. The lesion may be accompanied by inflammatory infiltrates.

## 英文原文 · Recommendation
When present, this lesion should be diagnosed and graded. Exacerbation by chemical agents warrants documentation in the pathology narrative. The affected lobe(s) should be identified if possible and indicated in the tissue identification. If paired lobes are involved, the diagnosis should indicate that the change is bilateral, with severity based on the more severely affected lobe.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0787.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0791.jpg

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