# 纤维化（Fibrosis）

- 器官 / 系统：唾液腺 / 消化系统（salivary-gland / alimentary-system）
- NTP 数据编号：ntp-0242
- 规范 URL：https://www.labsmart.cn/ntp/salivary-gland-fibrosis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#salivary-gland-fibrosis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/salivary-gland/Fibrosis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
纤维化可见于唾液腺内及周围（Figure 1、Figure 2），且常取代腺体组织。

## 病变描述（中文）
纤维化可见于唾液腺内及周围（Figure 1、Figure 2），且常取代腺体组织。它可与严重炎症和坏死同时出现。在某些慢性病例中，炎症和坏死已消退，纤维化表现为基本无细胞的嗜酸性组织。此类情况下，受累腺体或小叶可能较小，且腺泡可能发生萎缩。

## 诊断与分级建议（NTP 共识，中文）
凡纤维化作为唯一病变存在时，均应诊断并分级。然而，除非是病变的终末期，纤维化很少在没有同时存在的组织损伤或炎症的情况下出现。凡纤维化是退行性、坏死性或炎症性病变的重要组成成分时，均应诊断并分级。被认为继发于纤维化的腺体组织萎缩不应单独诊断，除非它是病变的显著组成成分。继发性病变应在病理学描述中记述。

## 英文原文 · Comment
Fibrosis can be found in and around the salivary glands ( Figure 1 and Figure 2 ) and often replaces glandular tissue. It may be seen concurrently with severe inflammation and necrosis. In some chronic cases, the inflammation and necrosis have resolved and the fibrosis appears as largely acellular, eosinophilic tissue. In such cases, the affected gland or lobule may be small, and there may be atrophy of the glandular acini.

## 英文原文 · Recommendation
Whenever present as the sole lesion, fibrosis should be diagnosed and graded. However, unless it is the end stage of a lesion, fibrosis is rarely seen without concurrent tissue damage or inflammation. Whenever it is a significant component of a degenerative, necrotic, or inflammatory lesion, fibrosis should be diagnosed and graded. Atrophy of glandular tissue that is considered secondary to fibrosis should not be diagnosed separately unless it is a prominent component of the lesion. Secondary lesions should be described in the pathology narrative.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0047.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0054.jpg

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