# 下颌下腺分泌耗竭（Submandibular Secretory Depletion）

- 器官 / 系统：唾液腺 / 消化系统（salivary-gland / alimentary-system）
- NTP 数据编号：ntp-0229
- 规范 URL：https://www.labsmart.cn/ntp/salivary-gland-submandibular-secretory-depletion.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#salivary-gland-submandibular-secretory-depletion
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/salivary-gland/Submandibular-SecretoryDepletion
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
分泌产物减少偶尔可见，且通常是一种细微的变化，需要仔细检查并与对照组比较才能发现。

## 病变描述（中文）
分泌产物减少偶尔可见，且通常是一种细微的变化，需要仔细检查并与对照组比较才能发现。受累细胞的细胞质染色一般较浅，且由于细胞质数量减少，细胞往往较小。在小管细胞中，嗜酸性细胞质颗粒的数量常减少。分泌耗竭与萎缩的不同之处在于，分泌耗竭是一种轻微的、弥漫性的变化，不伴有小管、间质组织或炎症细胞浸润的增加。分泌耗竭可同时发生于腺泡细胞和小管细胞（Figure 2）。

## 诊断与分级建议（NTP 共识，中文）
无论何时出现，分泌耗竭均应作出诊断，并根据细胞中分泌产物减少的程度和受累细胞的数量进行分级。迂曲管中的分泌耗竭根据嗜酸性胞质内颗粒耗竭的程度和受累迂曲（颗粒）管的数量进行分级。如果分泌耗竭仅限于腺泡细胞，则无需部位修饰词（诊断为“salivary gland, submandibular - secretory depletion”）。如果该变化仅限于小管，则诊断为“salivary gland, submandibular, duct - secretory depletion”。如果该变化同时存在于腺泡细胞和小管细胞中，则同时作出上述两项诊断。

## 英文原文 · Comment
A decrease in secretory product is seen occasionally and is often a subtle change requiring careful examination and comparison with controls to be detected. The cytoplasm of affected cells generally stains less intensely, and the cells are often smaller because of decreased amounts of cytoplasm. In the ductular cells, there is frequently a decrease in the number of eosinophilic, cytoplasmic granules. Secretory depletion differs from atrophy in that secretory depletion is a slight, diffuse change without an accompanying increase in ducts, interstitial tissue, or inflammatory cell infiltrate. Secretory depletion can occur in the acinar and ductular cells concurrently ( Figure 2 ).

## 英文原文 · Recommendation
Whenever present, secretory depletion should be diagnosed and graded based on the degree of decrease in secretory product in cells and number of cells involved. Secretory depletion in the convoluted ducts is based on degree of depletion of eosinophilic intracytoplasmic granules and number of convoluted (granular) ducts involved. If the secretory depletion is limited to the acinar cells, then no site modifier is necessary ("salivary gland, submandibular - secretory depletion" is diagnosed). If the change is limited to the ducts, then "salivary gland, submandibular, duct - secretory depletion" is diagnosed. If the change is present in both the acinar and ductal cells, then both diagnoses are made.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0070.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0067.jpg

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