# 淀粉样物质（Amyloid）

- 器官 / 系统：精囊 / 雄性生殖系统（seminal-vesicle / reproductive-system-male）
- NTP 数据编号：ntp-0482
- 规范 URL：https://www.labsmart.cn/ntp/seminal-vesicle-amyloid.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#seminal-vesicle-amyloid
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/seminal-vesicle/Amyloid
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
精囊淀粉样变性（amyloidosis）的特征是均质、嗜酸性至双染性无定形物质沉积，使上皮下间质扩张（箭头，Figure 1、Figure 2）。

## 病变描述（中文）
精囊淀粉样变性（amyloidosis）的特征是均质、嗜酸性至双染性无定形物质沉积，使上皮下间质扩张（箭头，Figure 1、Figure 2）。由于其为全身性疾病，淀粉样沉积物应存在于其他组织，如脾、肝、肾和肠，尤其是血管及血管周围部位。淀粉样变性是一种与年龄相关的变化，主要发生于小鼠，且不同小鼠品系的易感性存在差异。

## 诊断与分级建议（NTP 共识，中文）
淀粉样变性应予以诊断和分级，并且当治疗使其加重时，应在病理学叙述中予以描述。如果双侧精囊均受累，诊断应限定为双侧性，严重程度应基于受累更严重的精囊。

## 英文原文 · Comment
Amyloidosis in the seminal vesicle is characterized by deposition of homogeneous eosinophilic to amphophilic amorphous material that expands the subepithelial stroma (arrows, Figure 1 and Figure 2 ). Since it is a systemic condition, amyloid deposits should be present in other tissues, such as spleen, liver, kidney, and intestine, particularly in vascular and perivascular sites. Amyloidosis is an age-related change that occurs primarily in mice, with variable mouse strain susceptibility.

## 英文原文 · Recommendation
Amyloidosis should be diagnosed and graded and should be described in the pathology narrative when it is exacerbated by treatment. If both seminal vesicles are involved, the diagnosis should be qualified as bilateral and severity based on the more affected seminal vesicle

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0789.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0793.jpg

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