# 淀粉样物质（Amyloid）

- 器官 / 系统：皮肤 / 皮肤系统（skin / integumentary-system）
- NTP 数据编号：ntp-0370
- 规范 URL：https://www.labsmart.cn/ntp/skin-amyloid.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#skin-amyloid
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/integumentary-system/skin/Amyloid
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
淀粉样物质沉积（amyloid deposition）（Figure 1、Figure 2）是细胞无法清除不可溶性、错误折叠蛋白的结果。

## 病变描述（中文）
淀粉样物质沉积（amyloid deposition）（Figure 1、Figure 2）是细胞无法清除不可溶性、错误折叠蛋白的结果。它可与慢性炎症中急性期蛋白的过度产生相关，并且通常与系统性淀粉样变性相关。淀粉样物质沉积在大鼠中罕见，但在某些小鼠品系（如Swiss小鼠（CD-1））中作为常见的年龄相关变化出现，推测具有遗传易感性。皮肤中的淀粉样物质沉积几乎总是见于真皮，典型表现为大小不等的无定形、嗜酸性、细胞外物质蓄积，通常位于血管周围。组织化学染色（如刚果红（Congo red））和免疫组织化学染色有助于明确诊断。

## 诊断与分级建议（NTP 共识，中文）
淀粉样物质沉积只要存在就应诊断并赋予严重程度分级。

## 英文原文 · Comment
Amyloid deposition ( Figure 1 and Figure 2 ) occurs as a result of cells not being able to eliminate insoluble, misfolded protein. It can be associated with overproduction of acute-phase protein in chronic inflammation and is usually associated with systemic amyloidosis. Amyloid deposition is rare in rats but occurs as a common age-related change in some mouse strains, such as Swiss mice (CD-1), and presumably has a genetic predisposition. Amyloid deposition in the skin is almost always seen in the dermis and typically appears as variably sized accumulations of amorphous, eosinophilic, extracellular material that is usually perivascular. Histochemical (e.g., Congo red) and immunohistochemical stains are useful for definitive diagnosis.

## 英文原文 · Recommendation
Amyloid deposition should be diagnosed and assigned a severity grade whenever present.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0473.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0475.jpg

整理：北京天融慧通科技有限责任公司（LabSmart）｜ https://www.labsmart.cn