# 脓疱（Pustule）

- 器官 / 系统：皮肤 / 皮肤系统（skin / integumentary-system）
- NTP 数据编号：ntp-0375
- 规范 URL：https://www.labsmart.cn/ntp/skin-pustule.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#skin-pustule
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/integumentary-system/skin/Pustule
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
脓疱（pustule）（Figure 1、Figure 2）是角质层内有或没有血清的中性粒细胞的有组织积聚。

## 病变描述（中文）
脓疱（pustule）（Figure 1、Figure 2）是角质层内有或没有血清的中性粒细胞的有组织积聚。与囊泡（vesicle）一样，它们可能在接触腐蚀性物质后形成。脓疱通常出现在皮肤损伤后急性炎症的初始阶段，但在研究结束时往往不存在。脓疱破裂可能导致糜烂（erosion）或溃疡（ulcer），但由于糜烂或溃疡不一定起源于脓疱，脓疱的存在将为糜烂/溃疡的发病机制提供重要信息。

## 诊断与分级建议（NTP 共识，中文）
只要存在且没有明显的 underlying 糜烂或溃疡，就应诊断脓疱并根据大小和数量赋予严重程度分级。脓疱可能伴有真皮炎症、表皮增生或角化过度，所有这些都应作为单独的诊断记录。如果脓疱与糜烂/溃疡同时出现，则应记录并分级这两种诊断。

## 英文原文 · Comment
Pustules ( Figure 1 and Figure 2 ) are organized accumulations of neutrophils with or without serum within the stratum corneum. As with vesicles, they may form after exposure to caustic agents. Pustules typically occur in the initial stages of acute inflammation after skin injury but often are not present at the end of a study. Rupture of pustules may result in erosions or ulcers, but since erosions or ulcers do not necessarily arise from pustules, the presence of pustules would provide important information regarding the pathogenesis of the erosions/ulcers.

## 英文原文 · Recommendation
Whenever present without apparent underlying erosion or ulceration, pustules should be diagnosed and assigned a severity grade based on size and number. Pustules may be seen with dermal inflammation, epidermal hyperplasia, or hyperkeratosis, all of which should be recorded as separate diagnoses. If pustules are seen concurrently with erosions/ulcers, then both diagnoses should be recorded and graded.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0498.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0503.jpg

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