# 纤维化（Fibrosis）

- 器官 / 系统：前胃 / 消化系统（stomach-forestomach / alimentary-system）
- NTP 数据编号：ntp-0218
- 规范 URL：https://www.labsmart.cn/ntp/stomach-forestomach-fibrosis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#stomach-forestomach-fibrosis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-forestomach/Fibrosis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
纤维化（fibrosis）（Figure 1、Figure 2）通常发生在支持实质成分的结缔组织框架受到损伤时。

## 病变描述（中文）
纤维化（fibrosis）（Figure 1、Figure 2）通常发生在支持实质成分的结缔组织框架受到损伤时。在 Forestomach 中，鳞状上皮溃疡使下方黏膜下层暴露于胃内容物，胃内容物可损伤结缔组织成分并导致纤维化。严重或慢性炎症也可导致纤维化。坏死组织被含有许多新生毛细血管和成纤维细胞的纤维血管组织（肉芽组织）所取代，产生不成熟的胶原基质。随着纤维化成熟，其血管减少、胶原增多，直至最终基本无血管，主要由致密胶原束和相对少量的成纤维细胞组成。

## 诊断与分级建议（NTP 共识，中文）
当纤维化是唯一病变时，应诊断并分级。纤维化作为另一原发过程（如炎症、溃疡或肿瘤）的次要成分时，一般不应单独诊断，除非它是该病变的显著特征。

## 英文原文 · Comment
Fibrosis ( Figure 1 and Figure 2 ) generally occurs when there is damage to the connective tissue framework that supports the parechymal elements. In the forestomach, ulceration of the squamous epithelium exposes the underlying submucosa to gastric contents, which can damage the connective tissue elements and result in fibrosis. Severe or chronic inflammation can also lead to fibrosis. Necrotic tissue is replaced with fibrovascular tissue that contains many newly formed capillaries and fibroblasts (granulation tissue), producing an immature collagenous matrix. As fibrosis matures, it becomes less vascular and more collagenous until eventually it is fairly avascular and consists of primarily dense bundles of collagen and relatively low numbers of fibroblasts.

## 英文原文 · Recommendation
Whenever it is the sole lesion, fibrosis should be diagnosed and graded. Fibrosis as a minor component of another primary process such as inflammation, ulceration, or neoplasia should generally not be diagnosed separately unless it is a prominent feature of the lesion.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0088.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0093.jpg

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