# 异位组织（Ectopic Tissue）

- 器官 / 系统：腺胃 / 消化系统（stomach-glandular-stomach / alimentary-system）
- NTP 数据编号：ntp-0269
- 规范 URL：https://www.labsmart.cn/ntp/stomach-glandular-stomach-ectopic-tissue.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#stomach-glandular-stomach-ectopic-tissue
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-glandular-stomach/EctopicTissue
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
异位胰腺（Figure 1、Figure 2）、肝脏（Figure 3、Figure 4）或肠（Figure 5、Figure 6）罕见发生于腺胃的黏膜下层。

## 病变描述（中文）
异位胰腺（Figure 1、Figure 2）、肝脏（Figure 3、Figure 4）或肠（Figure 5、Figure 6）罕见发生于腺胃的黏膜下层。腺胃黏膜下层/固有层中出现肝细胞在B6C3F1小鼠及其他小鼠品系中已有报道，属罕见现象。在对照组和给药组、雌雄两性小鼠中均发现胃内肝细胞。该病变可能源于原胃细胞类型的化生，但更可能是发育缺陷的结果，被视为偶发性发现。所有病例均须排除肝脏肿瘤的侵袭或转移，即使细胞不呈现肿瘤性外观。由腺泡和导管细胞构成的异位胰腺组织也曾在小鼠胃黏膜下层中被描述。肠组织灶可发生于腺胃（Figure 5、Figure 6）。这被视为与胃内肝/胰腺异位灶类似的偶发性先天性病变。其与肠化生的鉴别在于其发生于黏膜上皮之外，且不伴有上皮的其他改变，如增生、非典型改变（异型增生）或胃癌。

## 诊断与分级建议（NTP 共识，中文）
异位组织无论何时出现，均应诊断但不进行分级。诊断应注明异位组织的类型。

## 英文原文 · Comment
Ectopic pancreas ( Figure 1 and Figure 2 ), liver ( Figure 3 and Figure 4 ) or intestines ( Figure 5 and Figure 6 ) occur rarely in the submucosa of the glandular stomach. Hepatocytes in the submucosa/lamina propria of the glandular stomach have been reported as a rare occurrence in the B6C3F1 mouse, as well as other mouse strains. Mice from control and treatment groups and both sexes have been found with gastric hepatocytes. This condition may arise from metaplasia of a primary stomach cell type but more likely is the result of a developmental defect and is considered an incidental finding. Invasion or metastasis from a liver neoplasm must be ruled out in all cases, even if the cells do not appear neoplastic. Ectopic pancreatic tissue, composed of acinar and ductal cells, has also been described in the submucosa of the mouse stomach. Foci of intestinal tissue can occur in the glandular stomach ( Figure 5 and Figure 6 ). This is considered an incidental congenital lesion similar to hepatic/pancreatic ectopic foci in the stomach. It is differentiated from intestinal metaplasia by occurrence outside of the mucosal epithelium and a lack of association with other changes in the epithelium, such as hyperplasia, atypical changes (dysplasia), or gastric carcinoma.

## 英文原文 · Recommendation
Whenever present, ectopic tissue should be diagnosed but not graded. The diagnosis should be modified with the type of ectopic tissue.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0114.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0119.jpg

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