水肿Edema · 腺胃 · 消化系统 · NTP ntp-0272

依据美国国家毒理学计划(NTP)Nonneoplastic Lesion Atlas 整理 · 中文译文与诊断建议 · 仅供科研使用,不用于临床诊断

一句话结论:水肿液(Edema fluid)在制片过程中常丢失,表现为组织中的透亮空隙,尽管蛋白含量较高的水肿液在切片中呈较强的嗜酸性。
诊断要点:每当水肿作为其本身的显著病变存在时,应当对其进行诊断和分级。严重程度分级取决于水肿液分离组织的范围及受累组织的总量。

病变描述

水肿液(Edema fluid)在制片过程中常丢失,表现为组织中的透亮空隙,尽管蛋白含量较高的水肿液在切片中呈较强的嗜酸性。水肿是调节血浆、间质和细胞之间正常液体分布的任一因素发生改变的结果,例如血管通透性增加、血管内流体静压升高、血管内渗透压降低和淋巴引流减少。因此,任何引起上述改变的化学物均可导致水肿。水肿常是炎症的早期组成部分。

诊断与分级建议(NTP 共识)

每当水肿作为其本身的显著病变存在时,应当对其进行诊断和分级。严重程度分级取决于水肿液分离组织的范围及受累组织的总量。与炎症相关的轻微水肿不单独诊断。

图谱

水肿(腺胃)组织学图谱 1
图 1 · 水肿 · 来源:NTP NNL Atlas
水肿(腺胃)组织学图谱 2
图 2 · 水肿 · 来源:NTP NNL Atlas

英文原文

展开 NTP 官方英文描述与建议

Comment:
Edema fluid is often lost in processing and appears as clear spaces in tissues, although edema fluid with a higher protein content will be more eosinophilic in sections. Edema is the result of alteration in any of the factors that regulate normal fluid distribution among the plasma, interstitium, and cells, such as increased vascular permeability, increased intravascular hydrostatic pressure, decreased intravascular osmotic pressure, and decreased lymphatic drainage. Therefore, any chemical resulting in the above changes can cause edema. Edema is often an early component of inflammation.

Recommendation:
Whenever present as a prominent finding of its own, edema should be diagnosed and graded. Severity grade depends on the extent of separation of the tissues by the edema fluid and overall amount of tissue affected. Minor edema associated with inflammation is not diagnosed separately.

来源与引用

原始条目:https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-glandular-stomach/Edema

图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。

建议引用格式:NTP Nonneoplastic Lesion Atlas. Edema (stomach-glandular-stomach). LabSmart 中文版: https://www.labsmart.cn/ntp/stomach-glandular-stomach-edema.html

中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#stomach-glandular-stomach-edema

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