# 纤维化（Fibrosis）

- 器官 / 系统：腺胃 / 消化系统（stomach-glandular-stomach / alimentary-system）
- NTP 数据编号：ntp-0279
- 规范 URL：https://www.labsmart.cn/ntp/stomach-glandular-stomach-fibrosis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#stomach-glandular-stomach-fibrosis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-glandular-stomach/Fibrosis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
纤维化（fibrosis）发生于胃部，是结缔组织和上皮细胞坏死的结果，这些细胞是再生组织实质成分所必需的。

## 病变描述（中文）
纤维化（fibrosis）发生于胃部，是结缔组织和上皮细胞坏死的结果，这些细胞是再生组织实质成分所必需的。坏死之后，该空间被纤维血管组织填充，其中含有许多新形成的毛细血管和成纤维细胞，产生不成熟的胶原基质。随着纤维化成熟，其血管减少、胶原增多，直至最终基本无血管，主要由致密胶原束和相对少量的成纤维细胞构成。溃疡形成和/或严重炎症可导致纤维化并伴有腺体组织丧失。

## 诊断与分级建议（NTP 共识，中文）
纤维化一旦出现即应诊断，并根据病变范围进行分级。纤维化作为另一原发病变（如炎症、溃疡形成或肿瘤形成）的次要成分时，不单独记录。纤维化区域中可能存在的腺体黏膜萎缩和炎症细胞不应单独诊断，除非它们是病变的显著成分。

## 英文原文 · Comment
Fibrosis occurs in the stomach as the result of necrosis of the connective tissue and epithelial cells required to regenerate the parenchymatous elements of the tissue. Following necrosis, the space is filled with fibrovascular tissue, which contains many newly formed capillaries and fibroblasts, producing an immature collagenous matrix. As fibrosis matures, it becomes less vascular and more collagenous until eventually it is fairly avascular and consists primarily of dense bundles of collagen and relatively low numbers of fibroblasts. Ulceration and/or severe inflammation can result in fibrosis with loss of glandular tissue.

## 英文原文 · Recommendation
Whenever present, fibrosis should be diagnosed and graded based on the extent of the lesion. Fibrosis as a minor component of another primary process, such as inflammation, ulceration, or neoplasia, is not documented separately. Atrophy of glandular mucosa and inflammatory cells that may be present in areas of fibrosis should not be diagnosed separately unless they are a prominent component of the lesion.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0132.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0128.jpg

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