肠化生Metaplasia Intestinal · 腺胃 · 消化系统 · NTP ntp-0281
诊断要点：无论何时出现，肠上皮化生均应予以诊断，并根据存在的化生腺体数量进行分级。
病变描述
肠上皮化生由形态学上与肠道相似的胃黏膜区域构成（Figure 1、Figure 2）。化生的黏膜衬里可有隐窝、不同程度发育的绒毛、杯状细胞（goblet cells）、潘氏细胞（paneth cells）和吸收细胞，并可能在酶学上与肠道相似。慢性炎症可导致胃小凹化生为黏液型增生性上皮，与肠道者相似。注意Figure 2中上皮细胞表面的微绒毛。在某些情况下，肠上皮化生可能与胃肿瘤形成相关。
诊断与分级建议（NTP 共识）
无论何时出现，肠上皮化生均应予以诊断，并根据存在的化生腺体数量进行分级。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Intestinal metaplasia consists of areas of gastric mucosa morphologically similar to the intestine ( Figure 1 and Figure 2 ). The metaplastic mucosal lining may have crypts, variably developed villi, goblet cells, paneth cells, and absorptive cells and may be enzymatically similar to the intestine. Chronic inflammation can result in metaplasia of the gastric pitsto a mucus-type hyperplastic epithelium, similar to that of the intestine. Notice the microvilli on surface of epithelial cells in Figure 2 . In some cases, intestinal metaplasia may be associated with gastric neoplasia.
Recommendation：
Whenever present, intestinal metaplasia should be diagnosed and graded based on the number of metaplastic glands present.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-glandular-stomach/MetaplasiaIntestinal
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Metaplasia Intestinal (stomach-glandular-stomach). LabSmart 中文版：
https://www.labsmart.cn/ntp/stomach-glandular-stomach-metaplasia-intestinal.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#stomach-glandular-stomach-metaplasia-intestinal