# 肠化生（Metaplasia Intestinal）

- 器官 / 系统：腺胃 / 消化系统（stomach-glandular-stomach / alimentary-system）
- NTP 数据编号：ntp-0281
- 规范 URL：https://www.labsmart.cn/ntp/stomach-glandular-stomach-metaplasia-intestinal.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#stomach-glandular-stomach-metaplasia-intestinal
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-glandular-stomach/MetaplasiaIntestinal
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
肠上皮化生由形态学上与肠道相似的胃黏膜区域构成（Figure 1、Figure 2）。

## 病变描述（中文）
肠上皮化生由形态学上与肠道相似的胃黏膜区域构成（Figure 1、Figure 2）。化生的黏膜衬里可有隐窝、不同程度发育的绒毛、杯状细胞（goblet cells）、潘氏细胞（paneth cells）和吸收细胞，并可能在酶学上与肠道相似。慢性炎症可导致胃小凹化生为黏液型增生性上皮，与肠道者相似。注意Figure 2中上皮细胞表面的微绒毛。在某些情况下，肠上皮化生可能与胃肿瘤形成相关。

## 诊断与分级建议（NTP 共识，中文）
无论何时出现，肠上皮化生均应予以诊断，并根据存在的化生腺体数量进行分级。

## 英文原文 · Comment
Intestinal metaplasia consists of areas of gastric mucosa morphologically similar to the intestine ( Figure 1 and Figure 2 ). The metaplastic mucosal lining may have crypts, variably developed villi, goblet cells, paneth cells, and absorptive cells and may be enzymatically similar to the intestine. Chronic inflammation can result in metaplasia of the gastric pitsto a mucus-type hyperplastic epithelium, similar to that of the intestine. Notice the microvilli on surface of epithelial cells in Figure 2 . In some cases, intestinal metaplasia may be associated with gastric neoplasia.

## 英文原文 · Recommendation
Whenever present, intestinal metaplasia should be diagnosed and graded based on the number of metaplastic glands present.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0143.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0145.jpg

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