# 纤维化（Fibrosis）

- 器官 / 系统：睾丸 / 雄性生殖系统（testis / reproductive-system-male）
- NTP 数据编号：ntp-0474
- 规范 URL：https://www.labsmart.cn/ntp/testis-fibrosis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#testis-fibrosis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/testis/Fibrosis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
虽然睾丸慢性炎症中可见少量纤维化，但Figure 1中所见的纤维化程度足以构成独立诊断。

## 病变描述（中文）
虽然睾丸慢性炎症中可见少量纤维化，但Figure 1中所见的纤维化程度足以构成独立诊断。纤维化通常与坏死和炎症后成纤维细胞和胶原替代睾丸实质有关。这可以是局灶性（focal）、多灶性（multifocal）或广泛的（Figure 1，星号），并可延伸至白膜。纤维化可能伴有矿化（箭头）和炎症（Figure 2）。分布可以是单侧或双侧。大鼠中，慢性可卡因或镉给药可诱导睾丸纤维化。

## 诊断与分级建议（NTP 共识，中文）
如果纤维化代表原发病变，且其范围和严重程度足以构成诊断依据，则应予以诊断并分级；如果其发生率和/或严重程度似乎与化学物给药相关，则应在病理学叙述中加以讨论。如果双侧睾丸均存在，则应诊断为双侧性。

## 英文原文 · Comment
While modest amounts of fibrosis can be seen in chronic inflammation of the testis, the degree of fibrosis present in Figure 1 warrants an independent diagnosis. Fibrosis is usually associated with replacement of testicular parenchyma by fibroblasts and collagen following necrosis and inflammation. This can be focal, multifocal, or extensive (Figure 1, asterisk), with extension to the tunica albuginea. The fibrosis may be accompanied by mineralization (arrow) and inflammation ( Figure 2 ). Distribution can be unilateral or bilateral. Testicular fibrosis is induced in rats by chronic cocaine or cadmium administration.

## 英文原文 · Recommendation
Fibrosis should be diagnosed and graded if it represents a primary lesion and when warranted by extent and severity and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. If present in both testes, it should be diagnosed as bilateral.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0807.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0808.jpg

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