# 间质细胞空泡化（Interstitial Cell Vacuolation）

- 器官 / 系统：睾丸 / 雄性生殖系统（testis / reproductive-system-male）
- NTP 数据编号：ntp-0478
- 规范 URL：https://www.labsmart.cn/ntp/testis-interstitial-cell-vacuolation.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#testis-interstitial-cell-vacuolation
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/testis/InterstitialCell-Vacuolation
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
间质细胞的细胞质空泡化可见于化学诱导的改变，最可能代表类固醇生成障碍。其一般表现为间质细胞增大、染色浅淡，细胞质呈泡沫状空泡化（Figure 1、Figure 2、Figure 3）。

## 病变描述（中文）
间质细胞的细胞质空泡化可见于化学诱导的改变，最可能代表类固醇生成障碍。其一般表现为间质细胞增大、染色浅淡，细胞质呈泡沫状空泡化（Figure 1、Figure 2、Figure 3）。在这些间质细胞空泡化的小鼠睾丸间质区，还可见合胞体巨细胞形成。Figure 1、Figure 2、Figure 3 中的转基因小鼠经炔雌醇处理。睾丸巨噬细胞也可发生空泡化，且与间质细胞无关。空泡化的细胞可能为间质细胞或巨噬细胞。二者可用 Periodic acid-Schiff 染色区分，该染色可染巨噬细胞而不染间质细胞。需注意，小鼠的正常间质细胞通常比大鼠的更大，且空泡化外观更明显。

## 诊断与分级建议（NTP 共识，中文）
间质细胞空泡化应当进行诊断和分级，并且如果其发生率和/或严重程度似乎与化学物给药相关，应当在病理学叙述中加以讨论。存在双侧病变时，诊断应当注明双侧性。

## 英文原文 · Comment
Cytoplasmic vacuolation of interstitial cells can be seen as a chemically induced change and most likely represents a disturbance in steroidogenesis. It generally consists of enlarged, pale-staining interstitial cells with foamy vacuolation of the cytoplasm ( Figure 1 , Figure 2 , and Figure 3 ). Syncytial giant cell formation is also present in the interstitial compartment of the testes of these mice with vacuolated interstitial cells. The transgenic mice in Figure 1 , Figure 2 , and Figure 3 were treated with ethinyl estradiol. Testicular macrophages can also become vacuolated, independent of interstitial cells. The vacuolated cells may represent interstitial cells or macrophages. These can be distinguished using a Periodic acid-Schiff stain, which stains macrophages but not interstitial cells. Note that normal interstitial cells of mice are generally larger and have a more vacuolated appearance than those of rats.

## 英文原文 · Recommendation
Interstitial cell vacuolation should be diagnosed and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. Diagnosis should indicate bilaterality when present. Pagination Figure 1 of 3 Next page › Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. The interstitial cells contain variably sized vacuoles. Enlarge Image All Images Enlarge All Images Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. The interstitial cells contain variably sized vacuoles. "> Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. The interstitial cells contain variably sized vacuoles. " /> Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. The interstitial cells contain variably sized vacuoles. Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. This higher magnification of Figure 1 shows the vacuolation of interstitial cells. "> Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. This higher magnification of Figure 1 shows the vacuolation of interstitial cells. " /> Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. This higher magnification of Figure 1 shows the vacuolation of interstitial cells. Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. This higher magnification image of Figure 2 shows the vacuoles in detail, as well as some golden brown pigment. "> Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. This higher magnification image of Figure 2 shows the vacuoles in detail, as well as some golden brown pigment. " /> Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. This higher magnification image of Figure 2 shows the vacuoles in detail, as well as some golden brown pigment.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0819.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0827.jpg

整理：北京天融慧通科技有限责任公司（LabSmart）｜ https://www.labsmart.cn