# 滤泡变性（Follicle Degeneration）

- 器官 / 系统：甲状腺 / 内分泌系统（thyroid-gland / endocrine-system）
- NTP 数据编号：ntp-0063
- 规范 URL：https://www.labsmart.cn/ntp/thyroid-gland-follicle-degeneration.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#thyroid-gland-follicle-degeneration
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/thyroid-gland/Follicle-Degeneration
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
滤泡变性包括滤泡扩张和正常滤泡形态丧失、相邻滤泡融合以及胶质染色强度减弱（Figure 1、Figure 2）。

## 病变描述（中文）
滤泡变性包括滤泡扩张和正常滤泡形态丧失、相邻滤泡融合以及胶质染色强度减弱（Figure 1、Figure 2）。该病变在小鼠中常见，在大鼠中不常见。在与处理相关的滤泡变性已在至少一项 NTP 小鼠亚慢性研究中出现；在该研究中，它与甲状腺色素沉着相关。在慢性研究中，对照组和处理组小鼠中已出现大量病例，其中一些病例中，衬覆退化扩张滤泡的上皮细胞具有纤毛（Figure 2，箭头）。

## 诊断与分级建议（NTP 共识，中文）
无论何时出现，这种退行性改变都应记录并分级。如果变性为双侧性，应在诊断中指明，且严重程度分级应基于受累最严重的腺体。

## 英文原文 · Comment
Follicular degeneration consists of dilatation and loss of normal follicular shape, coalescence of adjacent follicles, and decreased intensity of colloid staining ( Figure 1 and Figure 2 ). It occurs commonly in mice but uncommonly in rats. Treatment-associated follicular degeneration has occurred in at least one NTP subchronic study in mice; in that study it was associated with thyroid pigmentation. A large number of cases have occurred in control and treated mice in chronic studies, and in some the epithelial cells lining the degenerating dilated follicles are ciliated ( Figure 2 , arrows).

## 英文原文 · Recommendation
Whenever present, this degenerative change should be documented and graded. If the degeneration is bilateral, it should be indicated in the diagnosis, and the severity grade should be based on the most severely affected gland.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0295.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0299.jpg

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