# 牙髓血栓（Pulp Thrombus）

- 器官 / 系统：牙齿 / 消化系统（tooth / alimentary-system）
- NTP 数据编号：ntp-0258
- 规范 URL：https://www.labsmart.cn/ntp/tooth-pulp-thrombus.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#tooth-pulp-thrombus
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/tooth/Pulp-Thrombus
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
牙髓内血管的血栓形成（thrombosis）（Figure 1、Figure 2，箭头）可导致牙髓梗死（infarction）、成牙本质细胞变性（odontoblast degeneration）（Figure 1，箭头所指）及坏死（necrosis）。

## 病变描述（中文）
牙髓内血管的血栓形成（thrombosis）（Figure 1、Figure 2，箭头）可导致牙髓梗死（infarction）、成牙本质细胞变性（odontoblast degeneration）（Figure 1，箭头所指）及坏死（necrosis）。牙髓内血管的特异性血栓形成在NTP研究中尚未见报道，但在化学物诱导的播散性血栓形成中可见，此时在多个器官中可识别出栓子。化学物诱导血栓形成发病机制中可能涉及的机制包括血管损伤和血流障碍。血管闭塞通常导致牙髓缺血性坏死和牙齿死亡。

## 诊断与分级建议（NTP 共识，中文）
牙髓内血管血栓应予以诊断，并根据其大小和数量进行分级。相关的梗死或坏死，或成牙本质细胞或其他细胞的变性，应分别予以诊断和分级。牙齿坏死/变性成分与血栓之间的关系应在病理学描述中明确说明。

## 英文原文 · Comment
Thrombosis of vessels in the tooth pulp ( Figure 1 and Figure 2 , arrows) can result in infarction of the pulp and odontoblast degeneration ( Figure 1 , arrowhead) and necrosis. Thrombosis specifically of vessels in the tooth pulp has not been seen in NTP studies, but it has been seen with disseminated, chemically induced thrombosis in which thrombi were identified in multiple organs. Mechanisms that may be involved in the pathogenesis of chemically induced thrombosis include vascular damage and disturbance of blood flow. Vascular occlusion generally results in ischemic necrosis of the pulp and death of the tooth.

## 英文原文 · Recommendation
Vascular thrombi in the tooth pulp should be diagnosed and graded based on their size and number. Associated infarction or necrosis or degeneration of the odontoblasts or other cells should be diagnosed and graded separately. The relationship between the necrosis/degeneration components of the tooth and the thrombi should be made clear in the pathology narrative.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0217.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0211.jpg

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