# 子宫内膜鳞状化生（Endometrium Metaplasia Squamous）

- 器官 / 系统：子宫 / 雌性生殖系统（uterus / reproductive-system-female）
- NTP 数据编号：ntp-0532
- 规范 URL：https://www.labsmart.cn/ntp/uterus-endometrium-metaplasia-squamous.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#uterus-endometrium-metaplasia-squamous
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/uterus/Endometrium-MetaplasiaSquamous
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
子宫内膜上皮的鳞状化生（squamous metaplasia）（Figure 1、Figure 2、Figure 3、Figure 4、Figure 5、Figure 6）可自发发生，也可由给予具有雌激素活性的化合物（如 genistein、diethylstilbestrol 和 dioxins

## 病变描述（中文）
子宫内膜上皮的鳞状化生（squamous metaplasia）（Figure 1、Figure 2、Figure 3、Figure 4、Figure 5、Figure 6）可自发发生，也可由给予具有雌激素活性的化合物（如 genistein、diethylstilbestrol 和 dioxins）后激素变化所致。维生素 A 缺乏亦可引起鳞状化生。该病变的特征为正常柱状子宫内膜上皮被鳞状上皮取代。部分病例中，子宫内膜腺体亦可受累（Figure 7、Figure 8）。鳞状上皮细胞及管腔内其他细胞碎片发生角化并不少见。鳞状化生常伴发炎症和子宫内膜囊性增生。

## 诊断与分级建议（NTP 共识，中文）
子宫、子宫内膜 - 化生，鳞状：只要存在即应诊断并给出严重程度分级。诊断中应包含修饰词“squamous”，以明确界定病变并消除潜在混淆。共存的变化如炎症和角化过度不应单独诊断，除非其严重程度足以支持单独诊断。

## 英文原文 · Comment
Squamous metaplasia of the endometrial epithelium ( Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , and Figure 6 ) can develop spontaneously and also occurs as a result of hormonal changes following administration of compounds with estrogenic activity, such as genistein, diethylstilbestrol, and dioxins. Vitamin A deficiency also causes squamous metaplasia. The lesion is characterized by the replacement of the normally columnar endometrial epithelium by squamous epithelium. In some cases, the endometrial glands can also be affected ( Figure 7 and Figure 8 ). Keratinization is not uncommon with squames and other cellular debris in the lumen. Inflammation and cystic hyperplasia of the endometrium are frequently seen with squamous metaplasia.

## 英文原文 · Recommendation
Uterus, Endometrium - Metaplasia, Squamous should be diagnosed and given a severity grade whenever present. The modifier "squamous" should be included in the diagnosis to clearly define the lesion and eliminate potential confusion. Coexisting changes such as inflammation and hyperkeratosis should not be diagnosed separately unless warranted by severity.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0675.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0676.jpg

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