# 纤维化（Fibrosis）

- 器官 / 系统：阴道 / 雌性生殖系统（vagina / reproductive-system-female）
- NTP 数据编号：ntp-0565
- 规范 URL：https://www.labsmart.cn/ntp/vagina-fibrosis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#vagina-fibrosis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/vagina/Fibrosis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
阴道纤维化（Vaginal fibrosis）（Figure 1、Figure 2），即纤维结缔组织或胶原沉积并伴有少量散在细胞，已在老年大鼠中观察到，且常伴有一些慢性炎症。

## 病变描述（中文）
阴道纤维化（Vaginal fibrosis）（Figure 1、Figure 2），即纤维结缔组织或胶原沉积并伴有少量散在细胞，已在老年大鼠中观察到，且常伴有一些慢性炎症。纤维化需与肿瘤性病变（纤维瘤或纤维肉瘤）相鉴别，后者为占位性改变；相反，纤维化通常为收缩性病变。

## 诊断与分级建议（NTP 共识，中文）
阴道——纤维化只要在其他病变不存在时出现，就应诊断。伴有慢性或慢性活动性炎症的纤维化，仅当炎症程度与纤维化程度不相称时（即纤维化比根据炎症严重程度所预期的更为严重）才应诊断。如果纤维化未单独诊断，则应在病理学叙述中描述。无论何时诊断，纤维化都应赋予严重程度分级。

## 英文原文 · Comment
Vaginal fibrosis ( Figure 1 and Figure 2 ), deposition of fibrous connective tissue or collagen with a few interspersed cells, has been observed in older rats and is often accompanied by some chronic inflammation. Fibrosis needs to be differentiated from neoplasia (fibroma or fibrosarcoma), which is a space-occupying change; in contrast, fibrosis is generally a contracting lesion.

## 英文原文 · Recommendation
Vagina - Fibrosis should be diagnosed whenever it occurs in the absence of other lesions. Fibrosis present accompanying chronic or chronic active inflammation should be diagnosed only when the degree of inflammation is not commensurate to that of fibrosis (i.e., the fibrosis is more severe than would be expected given the severity of the inflammation). If fibrosis is not diagnosed separately, it should be described in the pathology narrative. Whenever it is diagnosed, fibrosis should be assigned a severity grade.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0703.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0702.jpg

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