# 黏液化（Mucification）

- 器官 / 系统：阴道 / 雌性生殖系统（vagina / reproductive-system-female）
- NTP 数据编号：ntp-0568
- 规范 URL：https://www.labsmart.cn/ntp/vagina-mucification.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#vagina-mucification
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/vagina/Mucification
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
一般而言，阴道黏膜化（vaginal mucification）（Figure 1、Figure 2）由孕酮过多诱导。

## 病变描述（中文）
一般而言，阴道黏膜化（vaginal mucification）（Figure 1、Figure 2）由孕酮过多诱导。因此，它正常发生于动情前期、妊娠和假妊娠期间。它也见于高催乳素血症，例如由分泌催乳素的垂体肿瘤所引起者。其组织学特征为阴道黏膜表面上皮细胞发生变化，变为立方状或圆柱状并伴有明显的空泡化。空泡化的细胞含有PAS和/或Alcian blue阳性物质（黏蛋白）。在某些情况下，阴道黏膜化可能是受试物效应。空泡化的程度、上皮的厚度以及上皮与黏膜化层之间缺乏角化带，均提示该黏膜化并非正常周期性变化的一部分。

## 诊断与分级建议（NTP 共识，中文）
阴道 - 黏膜化：当其不被认为是正常动情周期、妊娠或假妊娠的组成部分，或病理学家认为其过度时，应当诊断并分级。

## 英文原文 · Comment
In general, vaginal mucification ( Figure 1 and Figure 2 ) is induced by progesterone excess. Therefore, it occurs normally during proestrus, pregnancy, and pseudopregnancy. It is also seen with hyperprolactinemia, such as that caused by a prolactin-secreting pituitary neoplasm. It is characterized histologically by changes in the superficial epithelial cells of the vaginal mucosa, which become cuboidal or cylindrical with prominent vacuolation. The vacuolated cells contain PAS- and/or Alcian blue-positive material (mucin). In some cases, the mucification of the vagina may be a treatment effect. The degree of vacuolation, the thickness of the epithelium, and the lack of a band of keratinization between the epithelium and the mucified layer are indicative that the mucification is not part of a normal cyclical change.

## 英文原文 · Recommendation
Vagina - Mucification should be diagnosed and graded when it is not considered a component of normal estrous cyclicity, pregnancy, or pseudopregnancy, or if it is considered excessive in the opinion of the pathologist.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0708.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0709.jpg

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