# 坏死（Necrosis）

- 器官 / 系统：阴道 / 雌性生殖系统（vagina / reproductive-system-female）
- NTP 数据编号：ntp-0560
- 规范 URL：https://www.labsmart.cn/ntp/vagina-necrosis.html
- 中文图谱总页锚点：https://www.labsmart.cn/ntp-atlas.html#vagina-necrosis
- 原始出处：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/vagina/Necrosis
- 授权：美国联邦政府作品，公有领域；引用请标注 NTP Nonneoplastic Lesion Atlas
- 适用说明：仅供科研使用，不用于临床诊断

## 一句话结论
阴道上皮坏死（Figure 1、Figure 2）罕见观察到。最典型的是继发于阴道内给予外源化学物、刺激性赋形剂和/或阴道内装置。

## 病变描述（中文）
阴道上皮坏死（Figure 1、Figure 2）罕见观察到。最典型的是继发于阴道内给予外源化学物、刺激性赋形剂和/或阴道内装置。阴道坏死的特征包括核固缩和/或核碎裂、胞质嗜酸性、细胞肿胀或皱缩、脱落细胞和/或管腔内细胞碎片。阴道坏死常伴有急性炎症，并可能导致糜烂/溃疡。

## 诊断与分级建议（NTP 共识，中文）
阴道上皮和肌层坏死应诊断并分级。如果坏死继发于其他病变，如炎症或肿瘤，则不应单独诊断。继发于坏死的病变，如炎症、出血或水肿，除非严重程度需要，否则不应单独诊断，而应在病理学描述中作为坏死的组成部分进行描述。

## 英文原文 · Comment
Necrosis of the vaginal epithelium ( Figure 1 and Figure 2 ) is rarely observed. It is most typically observed secondary to intravaginal administration of xenobiotics, irritating vehicles, and/or intravaginal devices. The features of vaginal necrosis include nuclear pyknosis and/or karyorrhexis, cytoplasmic eosinophilia, cellular swelling or shrinkage, exfoliated cells, and/or intraluminal cellular debris. Vaginal necrosis is often associated with acute inflammation and may result in erosion/ulcer.

## 英文原文 · Recommendation
Necrosis of the vaginal epithelium and muscularis should be diagnosed and graded. If the necrosis is secondary to another lesion, such as inflammation or neoplasia, it should not be diagnosed separately. Lesions that are secondary to necrosis, such as inflammation, hemorrhage, or edema, should not be diagnosed separately unless warranted by severity but should be described in the pathology narrative as a component of the necrosis.

## 配图
- https://www.labsmart.cn/ntp-atlas-images/ntp_0710.jpg
- https://www.labsmart.cn/ntp-atlas-images/ntp_0711.jpg

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