Rathke裂扩张Rathke's Cleft Dilation · 垂体 · 内分泌系统 · NTP ntp-0047
诊断要点：由于慢性研究可能包含宫内暴露，可能与受试物相关的发育改变可能影响Rathke裂的最终存在和外观。
病变描述
扩张的持续性Rathke裂在大鼠中相对常见，通常含有嗜酸性胶体样蛋白性物质。可能出现胆固醇裂隙（箭头，Figure 1、Figure 2）以及游离红细胞（Figure 3）。也可能存在垂体囊肿（见Pituitary Gland - Cyst）。
诊断与分级建议（NTP 共识）
由于慢性研究可能包含宫内暴露，可能与受试物相关的发育改变可能影响Rathke裂的最终存在和外观。因此，当该改变存在时应予以记录。如果该改变的发生或严重程度存在潜在的受试物相关影响，则适合进行严重程度分级。扩张的Rathke裂内的出血或胆固醇裂隙不应单独诊断，除非严重程度足以支持单独诊断。相关链接：Pituitary Gland - Cyst
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Dilated persistent Rathke’s clefts are relatively common in rats and typically contain eosinophilic colloid-like proteinaceous material. Cholesterol clefts (arrow, Figure 1 and Figure 2 ), as well as free erythrocytes ( Figure 3 ), may be present. Pituitary cysts may also be present (see Pituitary Gland - Cyst ).
Recommendation：
Since chronic studies may incorporate in utero exposure, developmental alterations potentially related to treatment could influence the ultimate presence and appearance of Rathke’s cleft. Thus, this change should be documented when present. A severity grade is appropriate if there is a potential treatment-related effect on the occurrence or severity of this change. Hemorrhage or cholesterol clefts within the dilated Rathke’s cleft should not be diagnosed separately unless warranted by severity. Related Links: Pituitary Gland - Cyst
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/pituitary-gland/Rathke%27sCleft-Dilation
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Rathke's Cleft Dilation (pituitary-gland). LabSmart 中文版：
https://www.labsmart.cn/ntp/pituitary-gland-rathke-s-cleft-dilation.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#pituitary-gland-rathke-s-cleft-dilation