纤维化Fibrosis · 肾上腺 · 内分泌系统 · NTP ntp-0084

Comment：
Adrenal gland fibrosis ( Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , and Figure 8 ) is an uncommon incidental finding in mice and rats. It is usually a sequela to other pathologic processes, such as necrosis ( Figure 8 ), atrophy, thrombosis ( Figure 5 and Figure 6 ), or inflammation. Adrenal gland fibrosis can be a focal to extensive change in the cortex and/or medulla ( Figure 1 , Figure 2 , Figure 5 , and Figure 6 ) and/or the capsule ( Figure 3 , Figure 4 , Figure 7 , and Figure 8 ). In all areas, fibrosis is characterized by focal to diffuse accumulations of fibrous connective tissue, which replace and/or distort normal tissue architecture. The fibrous connective tissue may be immature (with abundant fibroblasts and blood vessels and little collagen) to mature (primarily dense collagenous sheets with few fibrocytes and blood vessels).

Recommendation：
Adrenal gland fibrosis should be diagnosed and assigned a severity grade. A site modifier (i.e., cortex, medulla, or capsule) should be included in the diagnosis. If it is present in both the cortex and medulla, the site modifier may be omitted and the location described in the pathology narrative. A distribution modifier (e.g., focal) may be included in the diagnosis if necessary. Fibrosis secondary to other lesions (e.g., inflammation or necrosis) should not be diagnosed separately unless warranted by severity. Features of fibrosis (e.g., mineralization or pigment) should not be diagnosed separately, though they should be described in the pathology narrative.